- What is hydroxyurea-oral, and how does it work (mechanism of action)?
- What brand names are available for hydroxyurea-oral?
- Is hydroxyurea-oral available as a generic drug?
- Do I need a prescription for hydroxyurea-oral?
- What are the side effects of hydroxyurea-oral?
- What is the dosage for hydroxyurea-oral?
- Which drugs or supplements interact with hydroxyurea-oral?
- Is hydroxyurea-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about hydroxyurea-oral?
What is hydroxyurea-oral, and how does it work (mechanism of action)?
Hydroxyurea (Hydrea) is an oral medication used to treat several types of cancers including chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), head and neck cancer, malignant melanoma, ovarian cancer, and polycythemia vera (a disorder of the bone marrow). The exact mechanism by which hydroxyurea works to treat cancer is not understood. However, it is thought that hydroxyurea causes an immediate inhibition of DNA synthesis by inhibiting an enzyme called ribonucleotide reductase. Interrupting DNA synthesis reduces the growth of cancer cells.
In-addition to treating cancer, Droxia another oral form of hydroxyurea is used in the management of sickle cell disease. The exact mechanism by which hydroxyurea works to treat sickle cell disease is not understood. The FDA approved hydroxyurea in December 1967.
What brand names are available for hydroxyurea-oral?
Is hydroxyurea-oral available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for hydroxyurea-oral?
What are the side effects of hydroxyurea-oral?
Known side effects include:
- bone marrow suppression (drop in white blood cell, red blood cell and platelet counts),
- sores in the mouth,
- skin rash,
- swelling in the hands, feet, legs and face,
- changes in skin pigmentation,
- hair loss,
- painful urination,
- liver problems,
- shortness of breath,
- metabolic disturbances, and
- kidney problems.
Quick GuidePancreatic Cancer Symptoms, Causes, and Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.