hydroxyurea (Hydrea, Droxia)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: hydroxyurea
BRAND NAME: Hydrea, Droxia
DRUG CLASS AND MECHANISM: Hydroxyurea (Hydrea) is an oral medication used to treat several types of cancers including chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), head and neck cancer, malignant melanoma, ovarian cancer, and polycythemia vera (a disorder of the bone marrow). The exact mechanism by which hydroxyurea works to treat cancer is not understood. However, it is thought that hydroxyurea causes an immediate inhibition of DNA synthesis by inhibiting an enzyme called ribonucleotide reductase. Interrupting DNA synthesis reduces the growth of cancer cells.
In-addition to treating cancer, Droxia another oral form of hydroxyurea is used in the management of sickle cell disease. The exact mechanism by which hydroxyurea works to treat sickle cell disease is not understood. The FDA approved hydroxyurea in December 1967.
PRESCRIBED FOR: Hydroxyurea is used to treat several types of cancer including chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), head and neck cancer, malignant melanoma, ovarian cancer, and polycythemia vera (a disorder of the bone marrow).
Medically Reviewed by a Doctor on 6/9/2015
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