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- What is hydroxychloroquine, and how does it work (mechanism of action)?
- What brand names are available for hydroxychloroquine?
- Is hydroxychloroquine available as a generic drug?
- Do I need a prescription for hydroxychloroquine?
- What are the side effects of hydroxychloroquine?
- What is the dosage for hydroxychloroquine?
- Which drugs or supplements interact with hydroxychloroquine?
- Is hydroxychloroquine safe to take if I'm pregnant or breastfeeding?
- What else should I know about hydroxychloroquine?
What is the dosage for hydroxychloroquine?
The usual adult dose for treating malaria is 800 mg initially, followed by 400 mg 6-8 hours later and then 400 mg at 24 hours and 48 hours. The dose for malaria prevention is 400 mg every week starting 1 or 2 weeks before exposure and for 4 weeks after leaving the high risk area.
The recommended adult dose for rheumatoid arthritis is 400-600 mg daily for 4-12 weeks followed by 200-400 mg daily.
Systemic lupus erythematosus is treated with 400 mg once or twice daily for several weeks then 200-400 mg daily. Hydroxychloroquine should be taken with food or milk in order to reduce stomach upset.
Which drugs or supplements interact with hydroxychloroquine?
Administration of hydroxychloroquine with penicillamine (Cuprimine, Depen) may increase penicillamine levels, increasing the risk of penicillamine side effects. The mechanism is unknown. Combining telbivudine (Tyzeka) and hydroxychloroquine may increase the risk of unexplained muscle pain, tenderness, or weakness because both drugs cause such side effects.
Hydroxychloroquine suppresses the immune system and should not be combined with drugs that also suppress the immune system or live vaccines.
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