hydroxocobalamin (injection, Cyanokit)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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DRUG CLASS AND MECHANISM:

  • Hydroxocobalamin is an injectable drug that reverses the effect of cyanide. It is an antidote used for treating cyanide poisoning. Cyanide is an extremely toxic poison. Cyanide poisoning can kill within minutes because it prevents cells in the body from using oxygen.
  • Hydroxocobalamin is made up off cyanocobalamin (vitamin B12) attached to cobalt. Hydroxocobalamin reverses the action of cyanide by binding to cyanide molecules. Each hydroxocobalamin molecule binds to one cyanide ion. The result of the chemical reaction is inactivation of cyanide and release of cyanocobalamin which is then excreted in the urine.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 4/15/2016
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