hydroxocobalamin (injection, Cyanokit)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREPARATIONS: Powder For Injection: 5 g/vial

DRUG INTERACTIONS: Hydroxocobalamin drug interaction studies have not been conducted.

PREGNANCY AND BREASTFEEDING SAFETY:

  • Hydroxocobalamin has not been adequately studied in pregnant women.
  • It is not known whether hydroxocobalamin is secreted in breast milk. Hydroxocobalamin may be given to nursing mothers in life-threatening situations. Breastfeeding should be stopped after receiving hydroxocobalamin.

STORAGE:

  • Powder should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
  • After mixing with liquid it may be stored for up to 6 hours at a temperature not exceeding 40 C (104 F).
  • It should not be frozen, and any unused portion should be discarded after 6 hours.

DOSING:

  • The recommended initial dose is 5 g (one vial) administered by intravenous infusion over 15 minutes.
  • A second 5 g dose may be administered if the response is not adequate.
  • The maximum total dose is 10 g.
Medically Reviewed by a Doctor on 4/15/2016
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