hydroxocobalamin (injection, Cyanokit) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREPARATIONS: Powder For Injection: 5 g/vial

DRUG INTERACTIONS: Hydroxocobalamin drug interaction studies have not been conducted.


  • Hydroxocobalamin has not been adequately studied in pregnant women.
  • It is not known whether hydroxocobalamin is secreted in breast milk. Hydroxocobalamin may be given to nursing mothers in life-threatening situations. Breastfeeding should be stopped after receiving hydroxocobalamin.


  • Powder should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
  • After mixing with liquid it may be stored for up to 6 hours at a temperature not exceeding 40 C (104 F).
  • It should not be frozen, and any unused portion should be discarded after 6 hours.


  • The recommended initial dose is 5 g (one vial) administered by intravenous infusion over 15 minutes.
  • A second 5 g dose may be administered if the response is not adequate.
  • The maximum total dose is 10 g.
Medically Reviewed by a Doctor on 4/15/2016

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