hydromorphone (Dilaudid, Dilaudid-5, Dilaudid-HP)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC NAME: hydromorphone hydrochloride

BRAND NAME: Dilaudid, Dilaudid-5, Dilaudid-HP, Exalgo



USES Hydromorphone is used for management of acute and moderate-to-severe chronic pain in patients when use of an opioid is appropriate.

SIDE EFFECTS: Side effects of hydromorphone are:

Other serious and important side effects of hydromorphone are respiratory depression and trouble breathing.

Since hydromorphone is a controlled narcotic, it carries a box warning of respiratory depression and abuse potential. Use with alcohol or other medications affecting central nervous system can worsen respiratory depression and may lead to death.

PREPARATIONS: Hydromorphone is available as immediate-release and extended-release tablets, injection, rectal suppository, and oral liquid forms.

  • Dilaudid (immediate release tablets): Available in 2 mg, 4 mg, and 8 mg strengths.
  • Exalgo (extended-release tablets): Available in 8 mg, 12 mg, 16 mg
  • Dilaudid (injection solutions): Available in 1mg/ml, 2 mg/ml, and 4 mg/ml strengths.
  • Dilaudid-HP (high potency injections): Available in two strengths: 250 mg powder for solution and 10 mg/ml injection solution.
  • Dilaudid-5 (oral solution): Available in 1 mg/ml strength in 473 ml bottle.
  • Dilaudid (rectal suppository): Available in 3 mg strength.
Medically Reviewed by a Doctor on 1/15/2016
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