hydrocortisone oral, Hydrocortone, Cortef (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Hydrocortisone also is used as a replacement for the naturally occurring hormone in patients whose adrenal glands are unable to produce sufficient amounts of corticosteroids.
DOSING: Hydrocortisone should be taken with food. The recommended dosage range is 10 mg to 300 mg per day depending on the disease administered in 3 to 4 divided doses.
DRUG INTERACTIONS: By interfering with the patient's immune response, hydrocortisone can impede the effectiveness of vaccinations. Hydrocortisone also can interfere with the tuberculin skin test and cause false negative results in patients with tuberculosis infection.
Rifampin and phenytoin (Dilantin, Dilantin-125) may increase the elimination of hydrocortisone from the body, reducing its effectiveness. Troleandomycin and ketoconazole may reduce the elimination of hydrocortisone, possibly leading to increased side effects.
PREGNANCY: Hydrocortisone has not been adequately evaluated during pregnancy.
NURSING MOTHERS: HHydrocortisone can appear in breast milk, and can have adverse effects on the baby. Therefore, mothers taking hydrocortisone should discontinue nursing.
SIDE EFFECTS: Hydrocortisone side effects depend on the dose, the duration and the frequency of administration. Short courses of hydrocortisone usually are well tolerated with few and mild side effects. Long term, high doses of hydrocortisone usually will produce predictable, and potentially serious side effects. Whenever possible, the lowest effective doses of hydrocortisone should be used for the shortest possible length of time to minimize side effects. Alternate day dosing also can help reduce side effects.
Side effects of hydrocortisone and other corticosteroids range from mild to serious. Side effects include:
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