DOSAGE: For proctitis the usual dosage is one enema applied at bedtime for 21 days or until symptoms resolve.
DRUG INTERACTIONS: The risk of drug interactions from hydrocortisone enema is low because it is administered rectally.
PREGNANCY AND BREASTFEEDING SAFETY:
- Hydrocortisone enema has not been adequately evaluated during pregnancy. Hydrocortisone enema taken orally can appear in breast milk, and can have adverse effects on the baby.
- It is not known whether hydrocortisone administered rectally is absorbed in sufficient amounts to appear in breast milk.
PREPARATIONS: Enema: 100 mg/60 ml
STORAGE: Hydrocortisone enema should be stored at room temperature, 20 C to 25 C (68 F to 77 F).
How does hydrocortisone enema work?
Hydrocortisone is a natural corticosteroid produced by the adrenal glands that are located adjacent to the kidneys. Corticosteroids have potent anti-inflammatory properties and are used in a wide variety of inflammatory conditions such as
- certain skin rashes, and
- allergic or inflammatory conditions of the nose and eyes.
There are numerous preparations of corticosteroids including oral tablets, capsules, liquids, topical creams and gels, inhalers and eye drops, as well as injectable and intravenous solutions. Hydrocortisone enema which is used for rectal conditions is discussed in this article.
The FDA approved hydrocortisone enema in January 1966.
REFERENCE: FDA Prescribing Information
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