hydrocodone/homatropine (Hycodan [discontinued] Tussigon)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Hydrocodone should not be administered within 14 days of stopping an MAOI.

PREGNANCY AND BREASTFEEDING SAFETY: There are no adequate studies of hydrocodone in pregnant women. Hydrocodone is excreted in breast milk, and, therefore, should be used cautiously by nursing mothers.

STORAGE: Hydrocodone/homatropine should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).

DOSING:

  • The dose for adults and children older than 12 years is one tablet (5 mg/1.5 mg) orally every 4 to 6 hours. The maximum dose is 30 mg/9 mg (6 tablets) in 24 hours.
  • Children 6 to 12 years of age receive a 1/2 tablet (2.5 mg/0.75 mg) every 4 to 6 hours not to exceed 3 tablets (15 mg/4.5 mg)

DRUG CLASS AND MECHANISM:

  • Hydrocodone is an opioid narcotic pain-reliever cough suppressant that is similar to codeine, oxycodone, morphine, methadone, fentanyl, and other opioids.
  • Hydrocodone, like other opioids, stimulates receptors on nerves in the brain to increase the threshold to pain (the amount of stimulation it takes to feel pain) and reduce the perception of pain (the perceived importance of the pain).
  • It also works directly on the cough center in the brain to reduce cough.
  • Homatropine blocks the action of acetylcholine, a chemical (neurotransmitter) that nerves use to communicate. It is added in low doses to discourage deliberate overdoses of hydrocodone.
  • The FDA approved hydrocodone/homatropine in July 1985.

Medically reviewed by Eni Williams, PharmD

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 1/15/2016
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