hydrocodone/homatropine - oral, Hycodan, Tussigon (cont.)

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Medical and Pharmacy Editor:

Homatropine blocks the action of acetylcholine, a chemical (neurotransmitter) that nerves use to communicate. It is added in low doses to discourage deliberate overdoses of hydrocodone. The FDA approved hydrocodone/homatropine in July 1985.



PREPARATIONS: Tablet: 5 mg /1.5 mg

STORAGE: Hydrocodone/homatropine should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Hydrocodone/homatropine is prescribed for the treatment of cough in adults and in children 6 years of age and older.

DOSING: The dose for adults and children older than 12 years is one tablet (5 mg/1.5 mg) orally every 4 to 6 hours. The maximum dose is 30 mg/9 mg (6 tablets) in 24 hours. Children 6 to 12 years of age receive a 1/2 tablet (2.5 mg/0.75 mg) every 4 to 6 hours not to exceed 3 tablets (15 mg/4.5 mg)

DRUG INTERACTIONS: Combining alcohol and other sedatives with hydrocodone can lead to increased sedation and even cause confusion. Hydrocodone should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase, for example, linezolid (Zyvox). Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death.

Hydrocodone should not be administered within 14 days of stopping an MAOI.

Medically Reviewed by a Doctor on 4/16/2014

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