hydrocodone and ibuprofen, Vicoprofen (cont.)

Pharmacy Author:

Eni Williams, PharmD, PhD

Eni Williams, PharmD, PhD

Dr. Eni Williams graduated from Creighton University in 1988 with a B.S. degree in pharmacy and a Doctor of Pharmacy from Howard University in 1994. She also obtained a Ph.D. in Public Policy in 2009 at the University of Maryland, Baltimore County.

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Medical and Pharmacy Editor:

Jay W. Marks, MD

Jay W. Marks, MD

Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREGNANCY: Hydrocodone and ibuprofen crosses the placenta. However, there is not enough information known about the effects of hydrocodone and ibuprofen on the fetus. Physicians may choose to use hydrocodone and ibuprofen if the benefits outweigh potential risks.

NURSING MOTHERS: It is not known if hydrocodone is secreted in breast milk.

SIDE EFFECTS: The most frequent side effects experienced with hydrocodone include lightheadedness, dizziness, sedation, nausea, dyspepsia (indigestion), vomiting, anxiety, nervousness, and somnolence (drowsiness). Other side effects include constipation and spasm of the ureter, which can lead to difficulty in urinating.

The most common side effects of ibuprofen involve the gastrointestinal system. It can cause ulcerations, abdominal pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding. Sometimes, stomach ulceration and bleeding can occur without abdominal pain, and black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears (tinnitus), and lightheadedness can also occur.

Hydrocodone can depress breathing, and is used with caution in the elderly, debilitated patients and those with a history of ulcer or serious lung disease. Hydrocodone can impair thinking and the physical abilities required for driving or operating machinery. Hydrocodone may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief.

Reference: FDA Prescribing Information

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