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GENERIC NAME: HYDROCHLOROTHIAZIDE W/TRIAMTERENE - ORAL (HI-dro-klor-oh-THIGH-uh-zide WITH try-AM-ter-een)

BRAND NAME(S): Dyazide, Maxzide

Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert

WARNING: This medication can raise your body's potassium levels. This effect is more likely to occur in patients with kidney disease, diabetes, or serious illness or in the elderly. Potassium levels must be closely monitored on a regular basis while taking this medication. If not treated, high potassium levels can sometimes be fatal. Seek immediate medical attention if you develop any of these rare but serious symptoms: muscle weakness, very slow heartbeat.

USES: This medication is a combination of two "water pills" (diuretics). It increases the amount of urine you make, which causes your body to get rid of excess water. Hydrochlorothiazide/triamterene is used in patients who have developed or are at risk for developing serious potassium loss with hydrochlorothiazide treatment alone. This drug is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication also reduces swelling/fluid retention (edema) seen with conditions such as congestive heart failure, liver disease, or kidney disease. This can help to improve symptoms such as trouble breathing.

HOW TO USE: Take this medication by mouth with or without food, usually once a day, or as directed by your doctor. The dosage is based on your medical condition and response to therapy. It is best to take this medication early in the day, before 4-6PM, to prevent having to wake up during the night to urinate. Consult your doctor or pharmacist if you have questions about your dosing schedule. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time of the day as directed. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Do not stop taking this medication without consulting your doctor. Cholestyramine and colestipol can decrease the absorption of hydrochlorothiazide. If you are taking either of these drugs, separate hydrochlorothiazide/triamterene from cholestyramine by at least 4 hours and from colestipol by at least 2 hours. If your condition persists or worsens, contact your doctor or pharmacist.




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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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  • furosemide, Lasix - Describes the medication furosemide (Lasix), a drug used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, and nephrotic syndrome.
  • Electrolytes - Read about blood electrolytes (sodium, potassium, chloride, and bicorbonate) and the effects of electrolyte imbalances like kidney failure, low blood pressure, hypokalemia, and hyperkalemia.
  • Congestive Heart Failure - Read about congestive heart failure symptoms like fatigue, abdomen, leg and ankle swelling, shortness of breath, sleeplessness, increased urination, nausea, abdominal pain, and decreased appetite.

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