What is the dosage for hydrochlorothiazide?
- Hydrochlorothiazide may be taken with or without food.
- The usual adult dose for hypertension is 12.5 to 50 mg once daily.
- The usual adult dose for treating edema is 25-100 mg once daily or in divided doses.
Which drugs or supplements interact with hydrochlorothiazide?
- Hydrochlorothiazide reduces the elimination of lithium (Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity.
- Nonsteroidal anti-inflammatory drugs (NSAIDs), for example, ibuprofen (Motrin), may reduce the blood pressure lowering effects of hydrochlorothiazide. Blood sugar levels can be elevated by hydrochlorothiazide, necessitating adjustment in the doses of medications that are used for treating diabetes.
- Combining hydrochlorothiazide with corticosteroids may increase the risk for low levels of blood potassium and other electrolytes. Low blood potassium (hypokalemia) can increase the toxicity of digoxin (Lanoxin).
- Cholestyramine (Questran, Questran Light) and colestipol (Colestid) bind to hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by 43% to 85%.
Is hydrochlorothiazide safe to use during pregnancy or while breastfeeding?
- There are no adequate studies of hydrochlorothiazide in pregnant women. Thiazides may increase the risk of fetal or neonatal jaundice, low platelet levels, and possibly other adverse reactions that have occurred in adults.
- Hydrochlorothiazide is excreted in breast milk. Intense diuresis using hydrochlorothiazide may reduce the production of breast milk. Otherwise hydrochlorothiazide is considered safe to use during nursing if required by the mother.
What else should I know about hydrochlorothiazide?
What preparations of hydrochlorothiazide are available?
- Tablets: 12.5, 25, 50 and 100 mg
- Capsules: 12.5 mg
How should I keep hydrochlorothiazide stored?
Hydrochlorothiazide should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in a tight, light-resistant container.
How does hydrochlorothiazide work?
- Hydrochlorothiazide is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid (edema). It works by blocking salt and fluid reabsorption from the urine in the kidneys, causing increased urine output (diuresis). Its mechanism of action in lowering high blood pressure is not well understood.
- Hydrochlorothiazide is used in combination with many other drugs
When was hydrochlorothiazide approved by the FDA?
- The FDA approved hydrochlorothiazide in February 1959.
Reference: FDA Prescribing Information
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