hydrochlorothiazide, (Hydrodiuril, Ezide, Hydro-Par [discontinued]), Microzide, and many others
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: hydrochlorothiazide
BRAND NAMES: Hydrodiuril (discontinued), Ezide (discontinued), Hydro-Par (discontinued), Microzide, and many combinations with other drugs
DRUG CLASS AND MECHANISM: Hydrochlorothiazide is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid (edema). It works by blocking salt and fluid reabsorption from the urine in the kidneys, causing increased urine output (diuresis). Its mechanism of action in lowering high blood pressure is not well understood. The FDA approved hydrochlorothiazide in February 1959.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 12.5, 25, 50 and 100 mg; Capsules: 12.5 mg
STORAGE: Hydrochlorothiazide should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in a tight, light-resistant container.
PRESCRIBED FOR: Hydrochlorothiazide is used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, corticosteroid medications, and nephrotic syndrome. It also is used alone or in conjunction with other blood pressure lowering medications to treat high blood pressure. Although hydrochlorothiazide is approved for treating edema in cirrhosis of the liver, it is rarely used because of the availability of other diuretics that are more effective. Hydrochlorothiazide can be used to treat calcium-containing kidney stones because it decreases the amount of calcium excreted by the kidneys in the urine and thus decreases the amount of calcium in urine to form stones.
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