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- What is hydralazine-oral, and how does it work (mechanism of action)?
- What brand names are available for hydralazine-oral?
- Is hydralazine-oral available as a generic drug?
- Do I need a prescription for hydralazine-oral?
- What are the uses for hydralazine-oral?
- What are the side effects of hydralazine-oral?
- What is the dosage for hydralazine-oral?
- Which drugs or supplements interact with hydralazine-oral?
- Is hydralazine-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about hydralazine-oral?
What is hydralazine-oral, and how does it work (mechanism of action)?
Hydralazine (Apresoline) is an antihypertensive medication used to treat high blood pressure. It is a peripheral arterial vasodilator and causes relaxation of blood vessels which carry blood away from the heart and towards the organs and tissues. The exact mechanism of how hydralazine causes arterial smooth muscle relaxation is not yet understood. Hydrazine affects calcium movement within blood vessels. Calcium is required for muscle contraction and therefore disturbances in calcium movement may cause smooth muscle relaxation in the blood vessels. Hydralazine is selective for arterioles (small arteries), and the overall effects of treatment include a decrease in arterial blood pressure, and peripheral vascular resistance.
In addition to treating high blood pressure, hydralazine has shown to be beneficial for the treatment of congestive heart failure (CHF). Although ACE inhibitors are preferred for the treatment of CHF, hydralazine in combination with isosorbide dinitrate (Isordil, Isordil Titradose, Dilatrate-SR) is an alternative for patients who cannot tolerate ACE inhibitors.
Hydralazine was approved by the US Food and Drug Administration (FDA) in 1952 as an antihypertensive agent. It is commonly used for the treatment of hypertension in pregnancy. Parenteral or injectable hydralazine is used to treat hypertensive emergencies (severally high blood pressure) during pregnancy.
What brand names are available for hydralazine-oral?
Is hydralazine-oral available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for hydralazine-oral?
What are the uses for hydralazine-oral?
Hydralazine is used for the treatment of essential hypertension (high blood pressure), alone or in-combination with other anti-hypertensive medications. It is also used for treating hypertensive crisis and congestive heart failure.
What are the side effects of hydralazine-oral?
Common side effects of hydralazine are:
- tachycardia (rapid heartbeat), and
- angina pectoris (chest pain).
Other less commonly reported side effects include:
- paralytic ileus,
- low blood pressure,
- paradoxical pressor response,
- dyspnea (shortness of breath),
- peripheral neuritis,
- muscle cramps,
- psychotic reactions,
- difficulty urinating,
- blood disorders,
- hypersensitivity type reactions,
- nasal congestion,
- abnormal tear production (lacrimation) , and
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