hyaluronic acid, Restylane, Restylane-L, Perlane (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: The most common side effects of hyaluronic acid are reactions at the site of injection such as:

  • bruising,
  • redness,
  • pain,
  • itching,
  • tenderness, and
  • swelling.

Vitamin E supplements, St. John's Wort, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) such as Aleve and Motrin may increase bruising or bleeding after injection of hyaluronic acid. Therefore, patients should stop these drugs at least one week before the injections.

Post marketing adverse effects that have been reported include:

  • infection,
  • allergic
  • reactions,
  • necrosis (death of tissue), and
  • acne.



PREPARATIONS: Single use syringes

STORAGE: Hyaluronic acid should be stored at room temperature up to 25 C (77 F).

DOSING: Hyaluronic acid is administered by injection only by a physician. The amount of hyaluronic acid that is administered depends on the site that is being treated but it should not be more than 1.5 ml per naso-labial fold or 6 ml per treatment. For lip augmentation the maximum volume is 1.5 ml per lip not to exceed 3 ml per session.

DRUG INTERACTIONS: Drug interactions are not listed in the prescribing information. Hyaluronic acid is classified as a medical device.

PREGNANCY: Use of hyaluronic acid during pregnancy has not been evaluated.

NURSING MOTHERS: Use of hyaluronic acid by nursing mothers has not been evaluated.

Medically reviewed by Eni Williams, PharmD

Reference: Restylane Instructions For Use

Medically Reviewed by a Doctor on 2/25/2015

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