Human Immunodeficiency Virus (HIV, AIDS) (cont.)
Eric S. Daar, MD
Eric S. Daar, MD
Dr. Daar received his undergraduate degree from UCLA and medical degree from Georgetown University School of Medicine. He completed an internship and residency in internal medicine at Cedars-Sinai Medical Center and his clinical and research fellowship in infectious diseases at Cedars-Sinai Medical Center and UCLA.
In this Article
What is the history of HIV, and when was HIV discovered?
The history of the human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) dates back to 1981, when homosexual men with symptoms of a disease that now are considered typical of AIDS were first described in Los Angeles and New York. The men had an unusual type of lung infection (pneumonia) called Pneumocystis carinii (now known as Pneumocystis jiroveci) pneumonia (PCP) and rare skin tumors called Kaposi's sarcomas. The patients were noted to have a severe reduction in a type of cell in the blood (CD4 cells) that is an important part of the immune system. These cells, often referred to as T cells, help the body fight infections. Shortly thereafter, this disease was recognized throughout the United States, Western Europe, and Africa. In 1983, researchers in the United States and France described the virus that causes AIDS, now known as HIV, belonging to the group of viruses called retroviruses. While HIV infection is required to develop AIDS, the actual definition of AIDS is the development of a low CD4 cell count (<200 cells/mm3) or any one of a long list of complications of HIV infection ranging from a variety of so-called "opportunistic infections," cancers, neurologic symptoms, and wasting syndromes.
What tests are used in the diagnosis of HIV?
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In 1985, a blood test became available that measures
antibodies to HIV that are the body's immune response to the HIV. The test used most commonly for diagnosing infection with HIV is referred to as an ELISA. If the ELISA finds HIV antibodies, the results must be confirmed, typically by a test called a Western blot. HIV antibody tests remain the best method for diagnosing HIV infection. Recently, tests have become available to look for these same antibodies in saliva, some providing results within
one to 20 minutes of testing. A major advance toward increasing the number of people tested for HIV is the availability of the FDA-approved OraQuick home HIV antibody test that is
Although the tests for detecting HIV infection continue to improve, they still require that people volunteer for testing. It is estimated that approximately 20% of those infected with HIV in the United States are unaware of their infection because they have never been tested. In order to decrease the number that are unaware of their HIV infection status, in 2006, the Centers for Disease Control and Prevention recommended that all people between the ages of 13 and 64 years be provided HIV testing whenever they encounter the health care system for any reason. In addition, resources are available to facilitate people finding local HIV testing centers (http://www.hivtest.org).
Reviewed by Jay W. Marks, MD on 4/3/2013
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HIV - Diagnosis Question: What tests did you have to diagnose HIV? What was your reaction?
HIV - How it's Spread Question: If known, please share how you contracted HIV.
HIV - Tests Question: What tests are used to monitor your HIV?
HIV - Management Question: Please share the ways in which you manage your HIV.
HIV - Pregnancy Treatment Question: Please describe your experience with HIV treatment during pregnancy. Does your child have HIV?
HIV - Prevention Question: In what ways do you actively prevent HIV transmission?
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