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Hives
(Urticaria & Angioedema)

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Medical Editor:

Are Hives Always Caused by an Allergy?

Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

Hives are swollen, red or pink bumps, patches, or welts on the skin that usually appear suddenly. Itching is the most common symptom associated with hives, although some people report that hives cause a stinging or burning sensation. Hives are a very common reaction to all kinds of stimuli. While an allergic reaction can be a cause of hives, in the majority of outbreaks, the exact cause of hives is not known. Hives are also known as urticaria.

Hives form when a chemical called histamineis released by specialized cells known as mast cells. It is true that allergic reactionsultimately lead to the release of histamine, but other circumstances can result in the release of histamine, causing an outbreak of hives. Histamine acts by causing blood vessels to leak fluid into the nearby tissues. In the skin, small areas of swelling develop as a result of capillary (the smallest blood vessels) leakage.

In addition to allergic reactions to medications, foods, or other substances, hives may be triggered by direct physical stimulation such as temperature extremes, water, sun, and physical exercise. Having a viral infection can also cause an outbreak of hives, and even stressand nervousness have been associated with hives outbreaks. In the form of hives known as dermographia, or "skin writing," raised, itchy red welts with adjacent flares appear wherever the skin is scratched or where belts and other articles of clothing rub against the skin.

Hives facts

  • Hives (medically known as urticaria) are red, itchy, raised areas of skin that appear in varying shapes and sizes.
  • Hives are very common and most often their cause is elusive.
  • Hives can change size rapidly and to move around, disappearing in one place and reappearing in other places, often in a matter of hours.
  • Ordinary hives flare up suddenly.
  • Physical hives are hives produced by direct physical stimulation of the skin.
  • Treatment of hives is directed at symptom relief while the condition goes away on its own.
  • Antihistamines are the most common treatment for hives.
  • Hives typically are not associated with long-term or serious complications.

What are hives (urticaria) and angioedema?

Hives (medically known as urticaria) appear on the skin as wheals that are red, very itchy, smoothly elevated areas of skin often with a blanched center. They appear in varying shapes and sizes, from a few millimeters to several inches in diameter anywhere on the body.

It is estimated that 20% of all people will develop urticaria at some point in their lives. Hives are more common in women than in men. One hallmark of hives is their tendency to change size rapidly and to move around, disappearing in one place and reappearing in other places, often in a matter of hours. Individual hives usually last no longer than 24 hours. An outbreak that looks impressive, even alarming, first thing in the morning can be completely gone by noon, only to be back in full force later in the day. Very few, if any other skin diseases occur and then resolve so rapidly. Therefore, even if you have no evidence of hives to show the doctor when you get to the office for examination, the diagnosis can be established based upon the accurate accounting of your symptoms and signs. Because hives fluctuate so much and so fast, it is helpful to bring along a photograph of what the outbreak looked like at its worst.

Swelling deeper in the skin that may accompany hives is called angioedema. This swelling of the hands and feet, as well as the lips or eyelids, can be as dramatic as it is brief.

What causes hives and angioedema?

Hives are produced when histamine and other compounds are released from cells called mast cells, which are normally found in the skin. Histamine causes fluid to leak from the local blood vessels, leading to swelling in the skin.

Hives are very common. Although they can be annoying, they usually resolve on their own over a period of weeks and are rarely medically serious. Some hives are caused by allergies to such things as foods, medications, and insect stings, but in the majority of cases, no specific cause for them is ever found. Although patients may find it frustrating not to know what has caused their hives, maneuvers like changing diet, soap, detergent, and makeup are rarely helpful in preventing hives unless there is an excellent temporal relationship.

Having hives may cause stress, but stress by itself does not cause hives.

When to visit the doctor

In rare cases (some hereditary, others caused by bee stings or drug allergy), urticaria and angioedema are accompanied by a striking decrease in blood pressure (shock) and difficulty breathing. This is called anaphylaxis and may rapidly become a medical emergency. In this case, a visit to the emergency room or your doctor is necessary. Ordinary hives may be widespread and disturbing to look at, but the vast majority of cases of hives do not lead to life-threatening complications.

Pictures of hives
What does urticaria (hives) look like?


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