Histoplasmosis Glossary of Terms
Abdominal: Relating to the abdomen, the belly , that part of the body that contains all of the structures between the chest and the pelvis . The abdomen is separated anatomically from the chest by the diaphragm , the powerful muscle spanning the body cavity below the lungs .
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Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer ).
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Acute: Of abrupt onset, in reference to a disease. Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care.
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Adrenal gland: One of a pair of small glands, each of which sits on top of one of the kidneys. The adrenal is made up of an outer wall (the cortex) and an inner portion (the medulla).
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Alkaline phosphatase: An enzyme made in the liver , bone, and the placenta and normally present in high concentrations in growing bone and in bile. Alkaline phosphatase is released into the blood during injury and during such normal activities as bone growth and pregnancy . It is measured in a routine blood test.
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Alveoli: The plural of alveolus. The alveoli are tiny air sacs within the lungs where the exchange of oxygen and carbon dioxide takes place.
Angina: Chest pain due to an inadequate supply of oxygen to the heart muscle. The chest pain of angina is typically severe and crushing. There is a feeling just behind the breastbone (the sternum) of pressure and suffocation.
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Antifungal: A drug used to treat fungal infections.
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Antifungal medication: A drug used to treat fungal infections.
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Arthritis: Inflammation of a joint. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis. (see osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, pseudogout).
Aspergillosis: Infection with the fungus Aspergillus, seen especially in people with a deficient immune system.
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Aspergillus: A family of fungal organisms and molds, some of which can cause disease ( aspergillosis ).
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Asymptomatic: Without symptoms. For example, an asymptomatic infection is an infection with no symptoms.
Bacterial: Of or pertaining to bacteria. For example, a bacterial lung infection.
Bilateral: Having, or relating to, two sides. Bilateral is as opposed, for example, to unilateral (which means having, or relating to, one side).
Biopsy: The removal of a sample of tissue for purposes of diagnosis. (Many definitions of "biopsy" stipulate that the sample of tissue is removed for examination under a microscope. This may or may not be the case. The diagnosis may be achieved by other means such as by analysis of chromosomes or genes.)
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Blastomycosis: Infection with a fungus called Blastomyces dermatitidis. The infection causes symptoms in about 50% of cases. It usually presents as a flu-like illness with fever, chills, productive cough, myalgia , arthralgia and pleuritic chest pain. Some patients fail to recover and develop chronic pulmonary infection or widespread disseminated infection (affecting the skin, bones, and genitourinary tract). It occasionally affects the meninges which cover the brain and spinal cord.
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Blindness: Loss of useful sight. Blindness can be temporary or permanent. Damage to any portion of the eye, the optic nerve, or the area of the brain responsible for vision can lead to blindness. There are numerous (actually, innumerable) causes of blindness. The current politically correct terms for blindness include visually handicapped and visually challenged.
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Blood count: The calculated number of white or red blood cells (WBCs or RBCs) in a cubic millimeter of blood.
Bone marrow: The soft blood-forming tissue that fills the cavities of bones and contains fat and immature and mature blood cells, including white blood cells, red blood cells, and platelets. Diseases or drugs that affect the bone marrow can affect the total counts of these cells.
Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
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Capsule: Capsule has many meanings in medicine including the following: - In medicine, a membranous structure that envelops an organ, a joint, tumor, or any other part of the body. It is usually made up of dense collagen-containing connective tissue.
- In pharmacy, a solid dosage form in which the drug is enclosed in a hard or soft soluble container, usually of a form of gelatin.
- In microbiology, a coat around a microbe, such as a bacterium or fungus.
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Cardiac: Having to do with the heart.
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Cardiac output: The amount of blood that is pumped by the heart per unit time, measured in liters per minute (l/min).
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Cavities: Holes in the two outer layers of a tooth called the enamel and the dentin. The enamel is the outermost white hard surface and the dentin is the yellow layer just beneath enamel. Both layers serve to protect the inner living tooth tissue called the pulp, where blood vessels and nerves reside. Small cavities may not cause pain, and may be unnoticed by the patient. Larger cavities can collect food, and the inner pulp of the affected tooth can become irritated by bacterial toxins, foods that are cold, hot, sour, or sweet - causing toothache. Also referred to as caries.
CBC: A commonly used abbreviation in medicine that stands for complete blood count , a set values of the cellular (formed elements) of blood. These measurements are generally determined by specially designed machines that analyze the different components of blood in less than a minute.
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CDC: The Centers for Disease Control and Prevention , the US agency charged with tracking and investigating public health trends. The stated mission of the CDC is "To promote health and quality of life by preventing and controlling disease, injury, and disability." The CDC is a part of the U.S. Public Health Services (PHS) under the Department of Health and Human Services (HHS).
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Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane .
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Cerebral: Pertaining to the brain, the cerebrum or the intellect.
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Chemotherapy : 1. In the original sense, a chemical that binds to and specifically kills microbes or tumor cells. The term chemotherapy was coined in this regard by Paul Ehrlich (1854-1915).
2. In oncology, drug therapy for cancer. Also called "chemo" for short.
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Chest: The area of the body located between the neck and the abdomen . The chest contains the lungs , the heart and part of the aorta . The walls of the chest are supported by the dorsal vertebrae , the ribs , and the sternum .
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Chest pain: There are many causes of chest pain. One is angina which results from inadequate oxygen supply to the heart muscle. Angina can be caused by coronary artery disease or spasm of the coronary arteries. Chest pain can also be due to a heart attack (coronary occlusion) and other important diseases such as, for example, dissection of the aorta and a pulmonary embolism. Do not try to ignore chest pain and "work (or play) though it." Chest pain is a warning to seek medical attention.
Chills: feelings of coldness accompanied by shivering. Chills may develop after exposure to a cold environment or may accompany a fever.
Choroid: In the eye, a thin vascular layer between the sclera and the retina. The choroid supplies blood to the retina and conducts arteries and nerves to other structures in the eye.
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Complete blood count : A set values of the cellular (formed elements) of blood. These measurements are generally determined by specially designed machines that analyze the different components of blood in less than a minute.
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Compress: 1. As a noun, a cloth or another material applied under pressure to an area of the skin and held in place for a period of time. A compress can be any temperature (cold, luke warm, or hot) and it can be dry or wet. It may also be impregnated with medication or, in traditional medicine, an herbal remedy. Most compresses are used to relieve inflammation.
2. As a verb, to squeeze or press together. An injury can compress the spinal cord.
Cortisol: The primary stress hormone. Cortisol is the major natural GLUCOCORTICOID (GC) in humans.
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Cough: A rapid expulsion of air from the lungs typically in order to clear the lung airways of fluids, mucus, or material. Also called tussis.
CT scan: Computerized tomography scan. Pictures of structures within the body created by a computer that takes the data from multiple X-ray images and turns them into pictures on a screen. CT stands for computerized tomography.
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Cutaneous: Relating to the skin. As, for example, in cutaneous allodynia, a cutaneous papilloma, and cutaneous syndactyly. From the Latin cutis meaning skin.
Diagnosis: 1 The nature of a disease ; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies . 3 The identification of any problem. The diagnosis was a plugged IV.
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Dyspnea: Difficult or labored breathing; shortness of breath.
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Echocardiography: Echocardiography is a diagnostic test which uses ultrasound waves to make images of the heart chambers, valves and surrounding structures. It can measure cardiac output and is a sensitive test for inflammation around the heart (pericarditis). It can also be used to detect abnormal anatomy or infections of the heart valves.
Encephalopathy: Disease, damage, or malfunction of the brain. In general, encephalopathy is manifested by an altered mental state that is sometimes accompanied by physical changes. Although numerous causes of encephalopathy are known, the majority of cases arise from infection, liver damage, anoxia, or kidney failure. The term encephalopathy is very broad and, in most cases, is preceded by various terms that describe the reason, cause, or special conditions of the patient that leads to brain malfunction. For example, anoxic encephalopathy means brain damage due to lack of oxygen, and hepatic encephalopathy means brain malfunction due to liver disease. Depending upon the cause and severity of the condition, symptoms may range from mild alterations in mental status to severe and potentially fatal manifestations such as dementia, seizures, and coma.
Endemic: Present in a community at all times but in relatively low frequency. Something that is endemic is typically restricted or peculiar to a locality or region.
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Erythema: A redness of the skin resulting from inflammation, for example, as caused by sunburn.
Erythema multiforme: See: Stevens-Johnson syndrome .
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Excision: 1. Surgical removal, as in the excision of a tumor . 2. The removal as if by surgery, as in base excision repair .
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Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
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Feces: The medical and scientific term for the "excrement discharged from the intestines."
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Fever : Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Formalin: A 37% aqueous (water) solution of formaldehyde, a pungent gas, with the chemical formula HCHO, used as an antiseptic, disinfectant, and especially today as a fixative for histology (the study of tissues under the microscope).
Fungal: Pertaining to a fungus. For example, a fungal skin infection.
Fungus: A single-celled or multicellular organism. Fungi can be true pathogens (such as histoplasmosis and coccidioidomycosis) that cause infections in healthy persons or they can be opportunistic pathogens (such as aspergillosis, candidiasis, and cryptococcosis) that cause infections in immunocompromised persons (including cancer patients, transplant recipients, and persons with AIDS). An example of a common fungus is the yeast organism which causes thrush and diaper rash (diaper dermatitis). Fungi are also used for the development of antibiotics, antitoxins, and other drugs used to control various human diseases.
Gland: 1. A group of cells that secrete a substance for use in the body. For example, the thyroid gland. 2. A group of cells that removes materials from the circulation. For example, a lymph gland.
Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart valves: There are four heart valves. All are one-way valves. Blood entering the heart first passes through the tricuspid valve and then the pulmonary valve. After returning from the lungs, the blood passes through the mitral (bicuspid) valve and exits via the aortic valve.
Histoplasma: Full name: histoplasma capsulatum. A microscopic fungus that causes the disease histoplasmosis. The fungus is found throughout the world in river valleys and soil where bird or bat droppings accumulate. The spores of the fungus are released into the air when contaminated soil is disturbed (for example, by plowing fields, sweeping chicken coops, or digging holes) and the airborne spores can then be inhaled into the lungs, the primary site of infection. In the US, the fungus is so common that in parts of Kentucky and Tennessee nearly 90% of adults show evidence of exposure by a positive histoplasma skin test. The fungus can be transferred by organ transplantation.
Histoplasma capsulatum: See: Histoplasma.
Histoplasmosis: A disease caused by the fungus Histoplasma capsulatum. Most people with histoplasmosis have no symptoms. However, histoplasma can cause acute or chronic lung disease and progressive disseminated histoplasmosis affecting a number of organs. It can be fatal if untreated.
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HIV: Acronym for the Human Immunodeficiency Virus , the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus . No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the reverse transcriptase , the virus uses its RNA as a template for making complementary DNA which can integrate into the DNA of the host organism).
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Immune: Protected against infection. The Latin immunis means free, exempt.
Immune response: Any reaction by the immune system.
Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
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Immunocompromised: Having an immune system that has been impaired by disease or treatment.
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Infant: A child up to 2 years (24 months) of age.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung.
Lymph: An almost colorless fluid that travels through vessels called lymphatics in the lymphatic system and carries cells that help fight infection and disease.
Lymph node: Also sometimes referred to as lymph glands, lymph nodes are small rounded or bean-shaped masses of lymphatic tissue surrounded by a capsule of connective tissue . Lymph nodes are located in many places in the lymphatic system throughout the body. Lymph nodes filter the lymphatic fluid and store special cells that can trap cancer cells or bacteria that are traveling through the body in the lymph fluid. The lymph nodes are critical for the body's immune response and are principal sites where many immune reactions are initiated. During a physical examination, doctors often look for swollen lymph nodes in areas where lymph nodes are abundant, including the neck, around the collarbone , the armpit ( axilla ), and the groin .
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Macrophage: A type of white blood that ingests (takes in) foreign material. Macrophages are key players in the immune response to foreign invaders such as infectious microorganisms.
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Macular: Pertaining to the macula. A macula is a small spot. A macula on the skin is a small flat spot while the macula in the eye is a small spot where vision is keenest in the retina .
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Malaise: A vague feeling of discomfort, one that cannot be pinned down but is often sensed as "just not right."
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Marrow: The bone marrow.
Meningitis: Inflammation of the meninges, usually due to a bacterial infection but sometimes from viral, protozoan, or other causes (in some cases the cause cannot be determined).
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Microscopic: So small it cannot be seen without the aid of microscope. As opposed to macroscopic (large enough to be seen with naked eye). A tiny tumor is microscopic while a big tumor is macroscopic.
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Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.
Mycelia: The plural of mycelium.
NIH: The National Institutes of Health. The NIH is an important U.S. health agency. It is devoted to medical research. Administratively under the Department of Health and Human Services (HHS), the NIH consists of 20-some separate Institutes and Centers. NIH's program activities are represented by these Institutes and Centers.
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NIOSH: The National Institute for Occupational Safety and Health, a US Federal agency responsible for conducting research and making recommendations for the prevention of work-related disease and injury.
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Node: Literally a knot, a node is a collection of tissue. For example a lymph node, is a collection of lymphoid tissue. A nodule is a small node, a little collection of tissue.
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Obesity: The state of being well above one's normal weight.
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Ocular: Having to do with the eye.
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Ocular histoplasmosis syndrome: An eye disease that is a leading cause of vision loss, due to the spread of spores of the fungus Histoplasma capsulatum (histo) from the lungs to the eye where they lodge in the choroid (a layer of blood vessels that provides blood and nutrients to the retina).
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Organ: A relatively independent part of the body that carries out one or more special functions. The organs of the human body include the eye, ear, heart, lungs, and liver.
Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Pericardial: Referring to the pericardium, the sac of fibrous tissue that surrounds the heart. The inner surface of the pericardium is lined by a layer of flat cells (mesothelial cells). The pericardial sac normally contains a small amount of fluid which acts as a lubricant to allow normal heart movement within the chest. A pericardial effusion refers to the presence of too much pericardial fluid, a serous fluid of a pale yellow color, within the pericardium.
Pericarditis: Inflammation of the lining around the heart (the pericardium) causing chest pain and accumulation of fluid around the heart (pericardial effusion).
Phagocytosis: The process by which a cell engulfs particles such as bacteria , other microorganisms, aged red blood cells, foreign matter, etc. The principal phagocytes (cells that can engage in phagocytosis) include the neutrophils and monocytes (types of white blood cells ).
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Pleural: Pertaining to the pleura, the thin covering that protects the lungs. The term "pleural" is pronounced like "plural" (but does not have plural meanings).
Prognosis: 1. The expected course of a disease .
2. The patient's chance of recovery.
The prognosis predicts the outcome of a disease and therefore the future for the patient . His prognosis is grim, for example, while hers is good.
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Progressive: Increasing in scope or severity. Advancing. Going forward. In medicine, a disease that is progressive is going from bad to worse.
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Pulmonary: Having to do with the lungs. (The word comes from the Latin pulmo for lung).
Relapse: The return of signs and symptoms of a disease after a patient has enjoyed a remission . For example, after treatment a patient with cancer of the colon went into remission with no sign or symptom of the tumor, remained in remission for 4 years, but then suffered a relapse and had to be treated once again for colon cancer.
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Resection: Surgical removal of part of an organ.
Respiratory: Having to do with respiration, the exchange of oxygen and carbon dioxide. From the Latin re- (again) + spirare (to breathe) = to breathe again.
Retinal: Pertaining to the retina , the extraordinary layer of neurons (nerve cells) that line the back of the eye, which can sense light and create impulses capable of voyaging through the optic nerve to the brain where the impulses are recognized as an image.
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Sarcoidosis: A disease of unknown origin that causes small lumps (granulomas) due to chronic inflammation to develop in a great range of body tissues. Sarcoidosis can appear in almost any body organ, but most often starts in the lungs or lymph nodes. It also affects the eyes, liver and skin; and less often the spleen, bones, joints, skeletal muscles, heart and central nervous system (brain and spinal cord).
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Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device.
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Sputum: The mucus and other matter brought up from the lungs, bronchi, and trachea that one may cough up and spit out or swallow. The word "sputum" is borrowed directly from the Latin "to spit." Called also expectoration.
Subacute: Rather recent onset or somewhat rapid change. The term "subacute" is used in contrast to acute which indicates very sudden onset or rapid change and chronic which indicates indefinite duration or virtually no change. A chronic condition is one lasting 3 months or more, by the definition of the U.S. National Center for Health Statistics. In ancient Greece, the "father of medicine" Hippocrates distinguished diseases that were acute (abrupt, sharp and brief) from those that were chronic. This is still a very useful distinction. Subacute has been coined to designate the mid-ground between acute and chronic.
Surgeon: A physician who treats disease, injury, or deformity by operative or manual methods. A medical doctor specialized in the removal of organs, masses and tumors and in doing other procedures using a knife (scalpel). The definition of a "surgeon" has begun to blur in recent years as surgeons have begun to minimize the cutting, employ new technologies that are "minimally invasive," use scopes, etc.
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Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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Symptomatic: 1 With symptoms, as a symptomatic infection. 2 Characteristic, as behavior symptomatic of Huntington disease. 3 Directed at the symptoms, as symptomatic treatment.
Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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Therapy: The treatment of disease .
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Transplant: The grafting of a tissue from one place to another, just as in botany a bud from one plant might be grafted onto the stem of another. The transplanting of tissue can be from one part of the patient to another (autologous transplantation), as in the case of a skin graft using the patient's own skin; or from one patient to another (allogenic transplantation), as in the case of transplanting a donor kidney into a recipient.
Tuberculosis : A highly contagious infection caused by the bacterium called Mycobacterium tuberculosis. Abbreviated TB. Tubercles (tiny lumps) are a characteristic finding in TB. Diagnosis may be made by skin test, which if positive should will be followed by a chest X-ray to determine the status (active or dormant) of the infection. Tuberculosis is more common in people with immune system problems, such as AIDS, than in the general population. Treatment of active tuberculosis is mandatory by law in the US, and should be available at no cost to the patient through the public health system. It involves a course of antibiotics and vitamins that lasts about six months. It is important to finish the entire treatment, both to prevent reoccurrence and to prevent the development of antibiotic-resistant tuberculosis. Most patients with tuberculosis do not need to be quarantined, but it is sometimes necessary.
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Urine: Liquid waste. The urine is a clear, transparent fluid. It normally has an amber color. The average amount of urine excreted in 24 hours is from 40 to 60 ounces (about 1,200 cubic centimeters). Chemically, the urine is mainly an aqueous (watery) solution of salt (sodium chloride) and substances called urea and uric acid. Normally, it contains about 960 parts of water to 40 parts of solid matter. Abnormally, it may contain sugar (in diabetes), albumen (a protein) (as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.
Uveitis: Inflammation of the uvea, the part of the eye that collectively refers to the iris, the choroid of the eye, and the ciliary body. The uvea provides most of the blood supply to the retina. Uveitis as a rule signifies inflammation involving the iris, choroid, and ciliary body -- all three components of the uveal tract.
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Valley fever: A disease also called coccidioidomycosis (CM) due to a fungus called Coccidioides immitis. About 40% of people infected with this fungus develop symptoms. Most often they have an influenza-like illness with fever, cough, headaches , rash , and myalgias (muscle pains). Of those people with symptoms, 8% have severe lung disease requiring hospitalization and 7% develop disseminated infection (throughout the body).
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Vascular: Relating to the blood vessels of the body. The blood vessels of the body, as a group, are referred to as the vascular system.
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Weight loss: Weight loss is a decrease in body weight resulting from either voluntary (diet, exercise) or involuntary (illness) circumstances. Most instances of weight loss arise due to the loss of body fat, but in cases of extreme or severe weight loss, protein and other substances in the body can also be depleted. Examples of involuntary weight loss include the weight loss associated with cancer, malabsorption (such as from chronic diarrheal illnesses ), and chronic inflammation (such as with rheumatoid arthritis).
White blood cell: One of the cells the body makes to help fight infections. There are several types of white blood cells ( leukocytes ). The two most common types are the lymphocytes and neutrophils (also called polymorphonuclear leukocytes, PMNs, or "polys").
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X-ray: 1. High-energy radiation with waves shorter than those of visible light. X-rays possess the properties of penetrating most substances (to varying extents), of acting on a photographic film or plate (permitting radiography), and of causing a fluorescent screen to give off light (permitting fluoroscopy). In low doses X-rays are used for making images that help to diagnose disease, and in high doses to treat cancer . Formerly called a Roentgen ray. 2. An image obtained by means of X-rays.
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