High Blood Pressure Treatment (cont.)
John P. Cunha, DO, FACOEP
John P. Cunha, DO, FACOEP
John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.
In this Article
Alpha blockers lower blood pressure by blocking alpha-receptors in the smooth muscle of peripheral arteries throughout the tissues of the body. The alpha-receptors are part of the sympathetic nervous system, as are the beta-receptors. The alpha-receptors, however, serve to constrict the peripheral arteries and the alpha-blockers cause the peripheral arteries to widen (dilate) and lower the blood pressure.
Evidence suggests using alpha blockers alone as a first-line drug choice for hypertension may actually increase the risk of heart-related problems, such as heart attacks or strokes. Alpha blockers should not be used as the initial drug for the treatment of high blood pressure. Examples of alpha blockers include terazosin (Hytrin), prazosin (Minipress), and doxazosin (Cardura).
Alpha blockers are particularly useful in patients with enlargement of the prostate gland because these drugs reduce the problems associated with urinating. The alpha-receptors, however, serve to constrict the peripheral arteries and the alpha blockers cause the peripheral arteries to widen (dilate) and lower the blood pressure. Tamsulosin (Flomax) or alfuzosin (Uroxatral) are alpha blockers that work well in combination with other antihypertensive medications.
Clonidine (Catapres) is an antihypertensive drug that works centrally. That is, it works in a control center for the sympathetic nervous system in the brain. The drug is referred to as a central alpha agonist because it stimulates alpha-receptors in the brain. The result of this central stimulation is to decrease the sympathetic nervous system outflow and to decrease the stiffness (resistance) of the peripheral arteries. Clonidine lowers the blood pressure by relaxing (dilating or widening) the peripheral arteries throughout the body. This drug is useful as a second- or third-tier choice for lowering blood pressure when other antihypertensive medications have failed. It also may be useful on an as-needed basis to control or smooth out fluctuations in the blood pressure. This drug tends to cause dryness of the mouth and fatigue so some patients do not tolerate it. Clonidine comes in an oral form or as a sustained release skin patch.
Reviewed by Jay W. Marks, MD on 10/11/2012
Viewers share their comments
High Blood Pressure Treatment - Smoking Question: Are you a smoker or former smoker undergoing treatment for high blood pressure? After diagnosis, did you quit smoking?
High Blood Pressure Treatment - Alcohol Question: Do you have hypertension and also drink alcohol? Have you cut back since receiving a diagnosis?
High Blood Pressure Treatment - Coffee and Caffeine Question: In what ways do coffee and other caffeinated beverages affect your blood pressure?
High Blood Pressure Treatment - Medications Question: What medications and other types of treatment do you receive for hypertension?
High Blood Pressure Treatment - Diet Question: Did you add or eliminate certain foods from your diet to control your high blood pressure? Did it help?
High Blood Pressure Treatment - Experience Question: What kinds of treatments have been effective for your high blood pressure?
High Blood Pressure Treatment - Alternative Medicine Question: Describe any alternative or complementary medicine you use to treat your high blood pressure.
Get the latest health and medical information delivered direct to your inbox FREE!