- Angiotensin converting enzyme (ACE) inhibitors
- Angiotensin receptor blocker (ARB)
- Calcium channel blockers (CCBs)
- Alpha-beta blockers
Angiotensin converting enzyme (ACE) inhibitors
Angiotensin converting enzyme (ACE) inhibitors are medications that inhibit the activity of the enzyme angiotensin converting enzyme (ACE), which is important for controlling blood pressure.
Angiotensin II is a very potent chemical formed in the blood by ACE from, angiotensin I. When formed, angiotensin II causes the muscles surrounding blood vessels to contract, thus narrowing the vessels and increasing blood pressure. ACE inhibitors are medications that inhibit the activity of ACE which decreases the production of angiotensin II. As a result, ACE inhibitors cause the blood vessels to enlarge or dilate, and this reduces blood pressure. This lower blood pressure makes it easier for the heart to pump blood and can improve the function of a failing heart. In addition, the progression of kidney disease due to high blood pressure or diabetes is slowed.
Examples of ACE inhibitor drugs include:
- enalapril (Vasotec)
- captopril (Capoten)
- lisinopril (Zestril and Prinivil)
- benazepril (Lotensin)
- quinapril (Accupril)
- perindopril (Aceon)
- ramipril (Altace)
- trandolapril (Mavik)
- fosinopril (Monopril)
- moexipril (Univasc)
Angiotensin receptor blockers (ARBs)
Angiotensin II receptor blockers (ARBs) are medications that block the action of angiotensin II by preventing angiotensin II from binding to angiotensin II receptors on the muscles surrounding blood vessels. As a result, blood vessels enlarge (dilate), and blood pressure is reduced. Reduced blood pressure makes it easier for the heart to pump blood and can improve heart failure. In addition, the progression of kidney disease due to high blood pressure or diabetes is slowed. ARBs have effects similar to ACE inhibitors, but ACE inhibitors act by preventing the formation of angiotensin II rather than by blocking the binding of angiotensin II to muscles on blood vessels.
Examples of ARB drugs include:
- losartan (Cozaar)
- irbesartan (Avapro)
- valsartan (Diovan)
- candesartan (Atacand)
- olmesartan (Benicar)
- telmisartan (Micardis)
- eprosartan (Teveten)
- azilsartan (Edarbi)
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