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hepatitis A and hepatitis B (recombinant) vaccine (Twinrix)

Pharmacy Author: Omudhome Ogbru, PharmD

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP

Jerry R. Balentine, DO, FACEP

Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

What is the dosage for hepatitis-b-hepatitis-a vaccine-injectable?

Adults of 18 years of age or older:

Standard dosing: Standard dosing schedule consists of 3 doses of 1 ml each. Administer 1 ml, intramuscularly on deltoid muscle, at 0, 1, and 6 months.
Accelerated dosing: Accelerated dosing schedule consists 4 doses of 1 ml each. Administer 1 ml intramuscularly into the deltoid muscle on days 0, 7, and 21 to 30, followed by a 4th dose at month 12.

Safe and effective use of hepatitis A/B vaccine in patients younger than 18 years of age has not been established.

Which drugs or supplements interact with hepatitis-b-hepatitis-a vaccine-injectable?

: Hepatitis A/B vaccine vaccines should not be used with medications and therapies that suppress the immune system such as adalimumab (Humira), belimumab (Benlysta), cyclosporine (Gengraf, Neoral, Sandimmune), azathioprine (Imuran), irradiation, and high doses of steroids because suppressing the immune system reduces the effectiveness of hepatitis A/B vaccine.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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