heparin (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Medications that increase the risk of bleeding will add to the effects of heparin and further increase the risk of bleeding that is associated with heparin. Such medications include aspirin, clopidogrel (Plavix), warfarin (Coumadin), other anticoagulants, and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin; Advil), naproxen (Naprosyn), diclofenac (Voltaren), and others.

PREGNANCY: Heparin has not been adequately evaluated in pregnant women. Heparin should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Preservative-free heparin is recommended when heparin is needed during pregnancy.

NURSING MOTHERS: It is not known whether heparin is excreted into breast milk. However, due to its large molecular weight, it is thought that heparin is not likely to be excreted into breast milk. Preservative-free heparin is recommended when heparin is needed during breastfeeding.

SIDE EFFECTS: The most common side effects are hemorrhage (bleeding), thrombocytopenia (decrease platelet count), heparin induced thrombocytopenia (HIT), heparin induced thrombocytopenia and thrombosis (HITT), injection site discomfort/irritation, allergy or hypersensitivity type reactions, and increase in liver enzymes.

REFERENCE: FDA Prescribing Information


Medically Reviewed by a Doctor on 10/9/2014


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