heparin

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Medical and Pharmacy Editor:

GENERIC NAME: heparin sodium

BRAND NAME: Hemochron, Hep-Lock, Hep-Lock U/P, Heparin in 5% Dextrose, Heparin Lock Flush, HepFlush-10

DRUG CLASS AND MECHANISM: Heparin is a widely used injectable anticoagulant (stops the formation of blood clots). The blood coagulation system is composed of various steps and heparin acts at multiple sites in this process. Heparin prevents blood clots by blocking the action of two of the 12 clot-promoting proteins in blood (factors X and II) whose action is necessary for blood to clot. The FDA approved heparin in 1939.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Injectable Solution: 1000, 2500, 5000, 10000, 20000 units/ml.

Heparin Lock Flush: 10, 100 units/ml.

Premixed Solution: 20000 units/500 ml, 25000 units/250 ml, 25000 units/500 ml.

STORAGE: Heparin sodium injections should be stored at 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Heparin sodium injection is used for various conditions, including prevention and treatment of venous thrombosis and pulmonary embolism, thromboembolic complications or blood clots associated with atrial fibrillation (a type of irregular heart beat), treatment of disseminated intravascular coagulation, and prevention of blood clots during heart and arterial surgery. It is also used in prevention and treatment of peripheral arterial embolism or clots, prevention of blood clots during blood transfusion, dialysis, and in extracorporeal circulation. Heparin is also used for treating acute coronary syndromes.

DOSING: Doses vary considerably based on use and desired level of anticoagulation. Consult published guidelines for various uses (myocardial infarction, DVT, pulmonary embolism, for example) and the manufacturer's recommendations as dosage varies; some patients may require dosage adjustments if they have certain conditions (for example, renal or liver problems).

Medically Reviewed by a Doctor on 10/9/2014



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