Hemolytic Uremic Syndrome
(HUS)

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Hemolytic uremic syndrome (HUS) facts

  • Hemolytic uremic syndrome (HUS) is a condition characterized by destruction of red blood cells and kidney failure.
  • HUS often follows a digestive infection caused by E. coli OH157:H7, although there are other causes.
  • Symptoms of HUS include vomiting and diarrhea (often bloody), weakness, lethargy, and bruising (purpura). These symptoms are due to a combination of dehydration, anemia and uremia (the inability of the kidneys to clear waste products from the body).
  • Diagnosis of HUS is made by a combination of history, physical exam, and abnormal blood tests. There is no one test that makes the diagnosis of hemolytic uremic syndrome.
  • Treatment of HUS is supportive with intravenous fluids. Anemia may require blood transfusion and temporary dialysis may be necessary.
  • Children tend to recover from HUS, while adults with HUS may fare less well.
Reviewed by Melissa Conrad Stöppler, MD on 7/22/2011


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Shiga Toxin-Producing E. coli Infection Facts

Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

Escherichia coli, or E. coli for short, is a very common bacterium. There are hundreds of different strains of E. coli. Some are harmless while others cause serious illness. Non-pathogenic strains of E. coli -- those that do not cause disease -- are normal inhabitants of the intestinal tract in humans and animals. But certain strains of E. coli can cause severe diarrhea and infect the genital and urinary tracts.

Examples of Shiga toxin-producing E. coli outbreaks

The most notorious type of pathogenic E. coli is known as E. coli 0157:H7. The name refers to the chemical compounds found on the surface of the bacterium. This strain was identified in 1982 following an outbreak of diarrhea resulting from the eating of undercooked beef. The 0157:H7 E coli strain belongs to a group of bacteria known as "Shiga toxin-producing" E. coli, or STEC for short. They have also been referred to as verocytotoxic E. coli (VTEC) or enterohemorrhagic E. coli (EHEC). Outbreaks of E. coli 0157:H7-induced illness have been common in recent years. In 2011, a deadly outbreak began in Europe due to a rare strain of E coli, Shiga toxin-producing E. coli O104, or STEC O104, that produces a serious illness similar to that produced by E coli 0157:H7. At the time of the outbreak, which was centered in Germany and related to contaminated vegetables, the STEC 0104 strain had never been identified in the United States.

Examples of other outbreaks include:

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