Apheresis: The process of removing a specific component from blood and returning the remaining components to the donor , in order to collect more of one particular part of the blood than could be separated from a unit of whole blood. Also called hemapheresis or pheresis .
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Arthritis: Inflammation of a joint. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis. (see osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, pseudogout).
Autoimmune: Pertaining to autoimmunity, a misdirected immune response that occurs when the immune system goes awry and attacks the body itself.
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Blood count: The calculated number of white or red blood cells (WBCs or RBCs) in a cubic millimeter of blood.
Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".
Calcium: A mineral found mainly in the hard part of bones, where it is stored. Calcium is added to bones by cells called osteoblasts and is removed from bones by cells called osteoclasts. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting. Food sources of calcium include dairy foods, some leafy green vegetables such as broccoli and collards, canned salmon, clams, oysters, calcium-fortified foods, and tofu. According to the National Academy of Sciences, adequate intake of calcium is 1,200 milligrams a day (four glasses of milk) for men and women 51 and older, 1,000 milligrams a day for adults 19 through 50, and 1,300 milligrams a day for children 9 through 18. The upper limit for calcium intake is 2.5 grams daily.
Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane .
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Cryoglobulinemia: The presence in blood of abnormal proteins called cryoglobulins that, by definition, have the unusual properties of precipitating from the blood serum when it is chilled and redissolving upon rewarming. (Cryoglobulins are gamma globulins with a molecular weight of approximately 200,000.)
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Dermatomyositis: A chronic inflammatory disease of skin and muscle which is associated with patches of slightly raised reddish or scaly rash . The rash can be on the bridge of the nose, around the eyes, or on sun-exposed areas of the neck and chest. Classically, however, it is over the knuckles. When the characteristic inflammation of the muscle (myositis) occurs without skin disease, the condition is referred to as polymyositis.
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Donor: The giver of a tissue or organ, for example, of blood or a kidney.
Familial: A condition that is tends to occur more often in family members than expected by chance alone. A familial disease may be genetic (such as cystic fibrosis ) or environmental (such as tuberculosis ).
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Familial hypercholesterolemia: The most common inherited type of hyperlipidemia (high lipid levels in blood). One in every 500 children is born with familial hypercholesterolemia. The condition predisposes to premature arteriosclerosis including coronary artery disease with heart attacks at an unusually young age.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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HELLP syndrome: A syndrome featuring a combination of "H" for hemolysis (the breakdown of red blood cells), "EL" for elevated liver enzymes, and "LP" for low platelet count (an essential blood clotting element).
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Hypercholesterolemia: High blood cholesterol. This can be sporadic (with no family history) or familial.
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Immune: Protected against infection. The Latin immunis means free, exempt.
Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Leukemia : Cancer of the blood cells. The growth and development of the blood cells are abnormal. Strictly speaking, leukemia should refer only to cancer of the white blood cells (the leukocytes) but in practice it can apply to malignancy of any cellular element in the blood or bone marrow, as in red cell leukemia (erythroleukemia).
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Leukocytes: Cells that help the body fight infections and other diseases. Also called white blood cells (WBCs).
Lightheadedness: A feeling you are "going to faint." Lightheadedness is medically distinct from dizziness, unsteadiness, and vertigo. See: Dizziness, Unsteadiness, and Vertigo.
Low blood pressure : Any blood pressure that is below the normal expected for an individual in a given environment. Low blood pressure is also referred to as hypotension.
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Lupus: A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.
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Macroglobulinemia: A condition in which the blood contains high levels of large proteins and is too thick to flow through small blood vessels. The large protein is an antibody called macroglobulin or IgM. One type of macroglobulinemia is Waldenstrom macroglobulinemia, a type of cancer.
Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."
Myasthenia gravis: An autoimmune neuromuscular disorder characterized by fatigue and exhaustion of muscles. Myasthenia gravis is caused by a mistaken immune response to the nicotinic acetylcholine receptors (AChR), which are found in junctions between muscles and the nervous system . The body produces antibodies that attack these AChR receptors, preventing signals from reaching the muscles. Proof that the anti-AChR antibodies are responsible for myasthenia comes from the effect these antibodies can have on the unborn and the newborn.
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Myeloproliferative: Referring to the proliferation of the bone marrow cells that give rise to red blood cells, granulocytes (a type of white blood cells), and/or platelets (crucial to blood clotting). The term myeloproliferative is in contrast to lymphoproliferative which refers to proliferation of lymphoid cells and reticuloendothelial cells such as macrophages. Both terms -- myeloproliferative and lymphoproliferative -- can be applied to conditions that are entirely benign, premalignant, or frankly malignant.
Myeloproliferative disorders: Malignant diseases of certain bone marrow cells including those that give rise to the red blood cells, the granulocytes (types of white blood cells), and the platelets (crucial to blood clotting).
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Organ: A relatively independent part of the body that carries out one or more special functions. The organs of the human body include the eye, ear, heart, lungs, and liver.
Peripheral: Situated away from the center, as opposed to centrally located.
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Pheresis: Procedure in which the blood is filtered, separated, and a portion retained, with the remainder being returned to the individual.
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Plasma: The liquid part of the blood and lymphatic fluid, which makes up about half of its volume. Plasma is devoid of cells and, unlike serum, has not clotted. Blood plasma contains antibodies and other proteins. It is taken from donors and made into medications for a variety of blood-related conditions. Some blood plasma is also used in non-medical products.
Plasmapheresis: A procedure designed to deplete the body of blood plasma (the liquid part of the blood) without depleting the body of its blood cells. Whole blood is removed from the body, the plasma is separated from the cells, the cells are suspended in saline, a plasma substitute or donor plasma), and the reconstituted solution may be returned to the patient. The procedure is used to remove excess antibodies from the blood in lupus, multiple sclerosis, multiple myeloma, etc. Plasmapheresis carries with it the same risks as any intravenous procedure. The risk of infection increases with the use of donor plasma, which may carry viral particles despite screening procedures. The procedure is done in a clinic or hospital.
Platelet: An irregular, disc-shaped element in the blood that assists in blood clotting. During normal blood clotting, the platelets clump together (aggregate). Although platelets are often classed as blood cells, they are actually fragments of large bone marrow cells called megakaryocytes.
Polymyositis : A chronic inflammatory disease of muscle that begins when white blood cells , the immune cells of inflammation, spontaneously invade muscles, especially the muscles closest to the trunk or torso, resulting in sometimes severe muscle pain, tenderness and weakness.
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Pregnancy : The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Progressive: Increasing in scope or severity. Advancing. Going forward. In medicine, a disease that is progressive is going from bad to worse.
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Purpura: 1. A hemorrhagic area in the skin. The area of bleeding within the skin, by definition, is greater than 3 millimeters in diameter. The appearance of the purpura depends on age of the lesion. Early purpura is red and becomes darker, then purple, and brown-yellow as it fades. Purpura does not blanch when touched.
2. A condition characterized by purpura such as immune thrombocytopenic purpura and Schonlein-Henoch purpura.
Red blood cells: The blood cells that carry oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cells their red color (and their name).
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Rejection: In transplantation biology, the refusal by the body to accept transplanted cells, tissues or organs. For example, a kidney transplanted may be rejected.
Rheumatoid arthritis : An autoimmune disease which causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Autoimmune diseases occur when the body tissues are mistakenly attacked by its own immune system. The immune system is a complex organization of cells and antibodies designed normally to "seek and destroy" invaders of the body, particularly infections. Patients with these diseases have antibodies in their blood which target their own body tissues, where they can be associated with inflammation. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. While rheumatoid arthritis is a chronic illness (meaning it can last for years) patients may experience long periods without symptoms.
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Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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Systemic: Affecting the entire body. A systemic disease such as diabetes can affect the whole body. Systemic chemotherapy employs drugs that travel through the bloodstream and reach and affect cells all over the body.
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Therapeutic: Relating to therapeutics , that part of medicine concerned specifically with the treatment of disease . The therapeutic dose of a drug is the amount needed to treat a disease.
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Transplant: The grafting of a tissue from one place to another, just as in botany a bud from one plant might be grafted onto the stem of another. The transplanting of tissue can be from one part of the patient to another (autologous transplantation), as in the case of a skin graft using the patient's own skin; or from one patient to another (allogenic transplantation), as in the case of transplanting a donor kidney into a recipient.
Vasculitis: Plural: vasculitides. A general term for a group of diseases that feature inflammation of the blood vessels. Each of these diseases is defined by characteristic distributions of blood vessel involvement, patterns of organ involvement, and laboratory test abnormalities. The causes of these vasculitis diseases are usually not known, but immune system abnormality is a common feature.
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White blood cell: One of the cells the body makes to help fight infections. There are several types of white blood cells ( leukocytes ). The two most common types are the lymphocytes and neutrophils (also called polymorphonuclear leukocytes, PMNs, or "polys").
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- Complete Blood Count (CBC) - A complete blood count (CBC) measures the concentration of white blood cells, red blood cells, and platelets in the blood and aids in the diagnosis of conditions and diseases such as anemia, malignancies, and immune disorders.
- Rheumatoid Arthritis - Learn more about rheumatoid arthritis, an autoimmune disease that causes chronic joint inflammation, which has symptoms that include stiffness, fever, muscle and joint aches, loss of appetite, and fatigue. Treatment of rheumatoid arthritis incorporates the use of first-line drugs (aspirin and corticosteroids for pain and inflammation) and second-line drugs (methotrexate and hydroxychloroquine to prevent joint destruction and promote remission).
- Liver Transplant - Information on liver transplant, the tests required, finding a match, complication, antirejection medications, and the follow-up necessary.
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