H. pylori (Helicobacter Pylori ) Infection

  • Medical Author:
    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Quick GuideDigestive Disorders: Common Misconceptions

Digestive Disorders: Common Misconceptions

How does a person become infected with H. pylori?

H. pylori bacteria may cause a stomach infection in some individuals.H. pylori infections start with a person acquiring the bacterium from another person (via either the fecal-oral or oral-oral route). Although the majority of individuals that have these bacteria in their GI tracts have few if any symptoms (see symptoms), most people develop stomach inflammation (gastritis) from the body's response to the bacterium itself and to a cytotoxin termed Vac-A, a chemical that the bacterium produces. Researchers also suggest that stomach acid stimulates the bacterium to grow and produce the cytotoxin, and increases invasion of the lining of the stomach by the bacteria, with resulting inflammation, and ulcer formation. Other investigators have shown that these bacteria and their products cause alterations in the cells lining the stomach that when altered are associated with stomach and other cancers, although these are infrequently seen diseases.

The frequency of people infected may somehow be related to race. About 60% of Hispanics and about 54% of African Americans have detectable organisms as compared to about 20% to 29% of White Americans. In developing countries, children are very commonly infected. Continue Reading

Reviewed on 6/28/2016
References
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Cancer.gov. Helicobacter pylori and Cancer. Reviewed Sep 5, 2013
<http://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/h-pylori-fact-sheet>

Chey, W. et al. "American College Gastroenterology Guideline on the management of Helicobacter pylori Infection." Amer. J. Gastro, 102:1808-1825, 2007.
<http://s3.gi.org/physicians/guidelines/ManagementofHpylori.pdf>

FDA. FDA approves first Helicobacter pylori breath test for children. Feb 24, 2014
<http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm293278.htm>

Santacroce, L. "Helicobacter Pylori Infection." Medscape. Sep 11, 2014.
<http://emedicine.medscape.com/article/176938-overview>

Crowe, S. MD., et al. "Patient information: Helicobacter pylori infection and treatment (Beyond the Basics)." UpToDate. Oct 08, 2015.
<http://www.uptodate.com/contents/helicobacter-pylori-infection-and-treatment-beyond-the-basics>

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