Helicobacter Pylori (cont.)

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What does H. pylori cause in humans?

H. pylori infections start with a person acquiring the bacterium from another person (via either the fecal-oral or oral-oral route). Although the majority of individuals that have these bacteria in their GI tracts have few if any symptoms (see symptoms), most people develop stomach inflammation (gastritis) from the body's response to the bacterium itself and to a cytotoxin termed Vac-A, a chemical that the bacterium produces. Researchers also suggest that the stomach acid stimulates the bacterium in addition to the cytotoxin, and increases invasion of the lining of the stomach, inflammation, and ulcer formation. Other investigators have shown that these bacteria and their products are associated with alterations in the cells lining the stomach that when altered are associated with stomach and other cancers, although these are infrequently seen diseases.

The frequency of people infected may somehow be related to race. About 60% of Hispanics and about 54% of African Americans have detectable organisms as compared to about 20% to 29% of Anglo Americans. In developing countries, children are very commonly infected.

What are the symptoms of H. pylori infections?

Most individuals infected with H. pylori have few or no symptoms. They may experience a few episodes of gastritis (minor belching, bloating, nausea, vomiting, abdominal discomfort), but little or nothing else. Often, these symptoms simply cease. However, those individuals who have a more serious infection exhibit symptoms of stomach and duodenal ulcers or gastritis which include the following:

Other symptoms may include diarrhea, heartburn, and bad breath (halitosis). Symptoms of black, tarry stools and fatigue should cause a person to seek medical help or go to an emergency department to be evaluated for intestinal bleeding.

Medically Reviewed by a Doctor on 4/25/2014

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