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February 10, 2012

Heart Murmur

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What is a heart murmur?

A heart murmur is a continuous sound that is audible with a common stethoscope, produced when blood passes through particular areas of the heart. The heart has four chambers, two atria (singular = atrium) and two ventricles separated by a "skeleton" of cartilage that separates each chamber. This skeleton is made up of the atrial septum, the ventricular septum and four valves (aortic, pulmonary, mitral and tricuspid) that direct blood flow in a specific route within the heart allowing the most efficient use of each heart beat to pump blood to the rest of the body.

How the heart works

  • Each heart beat has two phases, systole when the heart pumps and diastole when the heart chambers fill with blood.

  • Blood enters the right atrium from the body via the vena cava.

  • It travels through the tricuspid valve into the right ventricle.

  • A systolic heartbeat sends the blood through the pulmonary valve, which separates the right ventricle and the pulmonary artery, to the lung.

  • In the lung, oxygen is delivered to red blood cells and carbon dioxide, a waste product of metabolism, is removed.

  • The oxygenated blood returns to the left atrium where it travels through the mitral valve into the left ventricle.

  • The systolic heartbeat also causes the left side of the heart to contract and send the blood through the aortic valve that separates the left ventricle and the aorta.

  • Blood passes through the aorta to the body delivering oxygen to the body's tissues.

The sound of a murmur is generated when blood flow within the heart is not smooth and turbulence occurs. Using a stethoscope, a health care practitioner may be able to hear a heart murmur during the physical examination. Of note, not all heart murmurs are abnormal or dangerous, but if one is present it may signal a structural abnormality of the heart.

Picture of the Heart and the Valves of the Heart

What causes a heart murmur?

Functional heart murmur

Many heart murmurs are harmless and referred to as innocent or functional. They are caused when blood rushes through the heart quickly during normal function while no heart disease may exist. There may be an underlying medical condition that can lead to an innocent murmur. These may include situations where the heart beats more quickly such as fever, anemia, hyperthyroidism, and pregnancy.

Congenital heart murmurs

Congenital heart murmurs are heard in the newborn. They may be due to abnormalities in the valves, septae or arteries, and veins that carry blood to and from the heart. In some complicated heart disease conditions there may be a combination of all three. Many congenital heart murmurs resolve spontaneously without medical intervention while others require surgical operations for repair.

Patent ductus arteriosus (PDA) may cause a heart murmur in a newborn. Prior to birth birth, the aorta and pulmonary artery are connected by a small artery, the ductus arteriosus, to complete fetal blood circulation. Shortly after birth, this artery is supposed to close. If other congenital heart abnormalities exist, the ductus may remain open to help maintain some blood circulation. Sometimes, when no congenital abnormalities exist, the ductus doesn't completely close and a murmur may exist. Many times the patent ductus arteriosus closes by itself over time. Occasionally, medications or surgery may be required to close off the patent ductus arteriosus.

Valve abnormalities

Abnormalities of the valves of the heart may cause a heart murmur. Any of the heart valves may be affected and clinical symptoms depend upon the severity of the valve damage and whether the blood flow pattern within the heart is maintained. Each valve problem often leads to a specific character and timing of heart murmur.

  • Valve stenosis is narrowing of a heart valve. This often occurs over time as the valve scars due to injury and scarring from infection such as in rheumatic fever or from a congenital birth defect. Calcification of a valve may also result in stenosis. This causes the heart muscle to work harder to push blood through the narrowed opening and possible heart failure.

  • Valve regurgitation (or insufficiency) is a valve that leaks causing blood to pass backward against the normal blood flow pattern in the heart. A valve may have both stenosis and regurgitation.

  • Valve sclerosis is the mild narrowing and stiffening of the valve (most often seen in the aortic valve) due to aging. It is associated with atherosclerotic heart disease.

  • Valve prolapse is a bowing of a valve that causes some leaking and most often involves the mitral valve.

  • Endocarditis is an infection of the lining of the heart that may involve and destroy a heart valve. The source of the infection is usually elsewhere in the body and it travels via the bloodstream to infect the heart. Most often, there is a previous underlying heart condition.

Holes in the walls of the heart (the septum that divides the heart chambers) can be the source of a heart murmur. Atrial septal defect (ASD) describes a hole in the wall that separates the collecting chamber of the heart while a ventricular septal defect (VSD) affects the wall dividing the pumping chamber.



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Heart Murmur

What is mitral valve prolapse?

Mitral valve prolapse (also known as "click murmur syndrome" and "Barlow's syndrome") is the most common heart valve abnormality, affecting five to ten percent of the world population. A normal mitral valve consists of two thin leaflets, located between the left atrium and the left ventricle of the heart. Mitral valve leaflets, shaped like parachutes, are attached to the inner wall of the left ventricle by a series of strings called "chordae." When the ventricles contract, the mitral valve leaflets close snugly and prevent the backflow of blood from the left ventricle into the left atrium. When the ventricles relax, the valves open to allow oxygenated blood from the lungs to fill the left ventricle.

In patients with mitral valve prolapse, the mitral apparatus (valve leaflets and chordae) becomes affected by a process called myxomatous degeneration. In myxomatous degeneration, the structural protein collagen forms abnormally and caus...

Read the Mitral Valve Prolapse (MVP) article »




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