Rheumatic Fever »
What is rheumatic fever?
Rheumatic fever (acute rheumatic fever or ARF) is an autoimmune disease that may occur after a
group A streptococcal throat infection that causes inflammatory lesions in
connective tissue, especially that of the heart, joints, blood vessels, and
subcutaneous tissue. The disease has been described since the 1500s, but the
association between a throat infection and rheumatic fever symptom development
was not described until the 1880s. It was associated with scarlet fever (rash
caused by streptococcal exotoxins) in the 1900s. Prior to the broad availability
of penicillin, rheumatic fever was a leading cause of death in children and one
of the leading causes of acquired heart disease in adults. The disease has many
symptoms and can affect different parts of the body, including the heart,
joints, skin, and brain. There is no simple diagnostic test for rheumatic
fever, so the American Heart Association's modified Jones criteria (f...
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