Hashimoto's Thyroiditis
Medical Revising Author: Ruchi Mathur, MD, FRCP(C)
Medical Editor: William C. Shiel, Jr., MD, FACP, FACR
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Hypothyroidism Symptoms
Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel, Jr, MD, FACP, FACR
The thyroid gland is a
butterfly-shaped organ situated on the front of the neck that secretes two hormones, thyroxine (also known as T4) and
triiodothyronine
(called T3), that are important in the control of metabolism.
Hypothyroidism is a condition in which the thyroid gland does not produce
adequate levels of these critical hormones.
Hypothyroidism is very common and is estimated to affect
3%-5% of the adult population. It is more common in women
than in men, and the risk of developing hypothyroidism increases with advancing
age.
Hypothyroidism is most commonly a result of an
autoimmune condition known as Hashimoto's thyroiditis, in which the body's
own immune cells attack and destroy the thyroid gland.
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Introduction to Hashimoto's thyroiditis
Hashimoto's thyroiditis is the most common cause of hypothyroidism in the
United States. It is named after the first doctor who described this condition,
Dr. Hakaru Hashimoto, in 1912.
What causes Hashimoto's thyroiditis?
Hashimoto's thyroiditis is a condition caused by inflammation of the
thyroid gland. It is an
autoimmune disease, which means that the body inappropriately attacks the thyroid
gland--as if it was foreign tissue. The underlying cause of the autoimmune
process still is unknown. Hashimoto's thyroiditis tends to occur in families, and is
associated with a clustering of other autoimmune conditions such as Type 1
diabetes, and celiac disease. Hashimoto's
thyroiditis is 5-10 times more common in women
than in men and most often starts in adulthood. Blood drawn from patients with
Hashimoto's throiditis reveals an increased number of antibodies to the enzyme, thyroid
peroxidase an enzyme (protein) found within the thyroid gland. As result of the
antibodies' interaction with the enzyme, inflammation develops in the thyroid
gland, the thyroid gland is destroyed, and the patient ultimately is rendered
hypothyroid (too little thyroid hormone).

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