haloperidol, Haldol (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Carbamazepine (Tegretol) may increase the elimination of haloperidol, rendering the haloperidol less effective. Rifampin (Rifadin) may decrease the elimination of haloperidol, increasing the risk of side effects from haloperidol.

PREGNANCY Neonates exposed to antipsychotics during the 3rd trimester may develop withdrawal symptoms and extrapyramidal symptoms.

NURSING MOTHERS: Halop Haloperidol is secreted into breast milk. It should not be used while breast feeding.

SIDE EFFECTS: The most common side effects associated with haloperidol are extrapyramidal effects (sudden, often jerky, involuntary motions of the head, neck, arms, body, or eyes), dizziness, hyperactivity, tiredness, and nausea. Sedation, weight gain, erectile dysfunction, menstrual irregularities, insomnia, gynecomastia, dry mouth, nausea, vomiting, and constipation are also common.

Haloperidol may cause a condition called "orthostatic hypotension" during the early phase of treatment (first week or two). Orthostatic hypotension causes patients to become dizzy upon arising from a lying or sitting position because of a drop in blood pressure.

Haloperidol also may cause abnormal heart beats, sudden death, seizures, decreases in red and white blood cells, and withdrawal symptoms.

Elderly patients with dementia-related psychosis and treated with antipsychotic drugs such as haloperidol are at an increased risk of death.

Reference: FDA Prescribing Information

Last Editorial Review: 2/23/2012

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