DRUG INTERACTIONS: See also How to Use section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.A product that may interact with this drug is: riociguat.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.Other medications can affect the removal of this medication from your body, which may affect how this medication works. Examples include cimetidine, disulfiram, fluvoxamine, interferon alpha, certain macrolide antibiotics (clarithromycin, erythromycin), mexiletine, nefazodone, St. John's wort, drugs to treat seizures (such as carbamazepine, phenobarbital, phenytoin), tacrine, zileuton, among others.Check the labels on all your medicines (such as cough-and-cold products, diet aids) because they may contain the same or similar ingredients (such as ephedrine, phenylephrine) that could increase the side effects of this medication. Ask your pharmacist about using those products safely.Also report the use of drugs which might increase seizure risk when combined with this medication including isoniazid (INH), phenothiazines (such as thioridazine), tramadol, tricyclic antidepressants (such as amitriptyline), among others. Consult your doctor or pharmacist for details.Cigarette smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.This medication may interfere with certain laboratory tests (such as stress tests, uric acid levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this medication.
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