guaifenesin/codeine - oral, Cheracol, Robitussin A-C

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GENERIC NAME: Guaifenesin and codeine phosphate.

BRAND NAME: Cheratussin AC, Tussi-Organidin NR, Mytussin AC.

DRUG CLASS AND MECHANISM: Guaifenesin with codeine is an oral, liquid cough medicine. Guaifenesin is an expectorant, which works by thinning and increasing the volume of mucus. Codeine is a narcotic cough suppressant that works by suppressing the cough reflex in the brain, eventually reducing the frequency of cough.



PREPARATIONS: Guaifenesin with codeine phosphate is available as an oral liquid. One teaspoon (5 ml) of liquid contains 10 mg of codeine phosphate and 100 mg or 300 mg of guaifenesin.

STORAGE: Guaifenesin and codeine liquid should be stored between 15 C to 30 C (59 to 86 F).

PRESCRIBED FOR: Guaifenesin with codeine temporarily relieves cough associated with colds as well as throat and bronchial irritation. It helps loosen mucus as well as suppress cough.


  • Adults and children 12 years of age and older: Take 2 teaspoon (10 ml) by mouth every 4 hours as needed.
  • Children 6 years to 12 years of age: Take 1 teaspoon (5 ml) by mouth every 4 hours as needed.
  • Children 2 years to 6 years of age: Consult a doctor.
  • Children under 2 years of age: Do not use.
  • Do not use more than 6 doses in a 24-hour period.

DRUG INTERACTIONS: Naltrexone (Riva) decreases the effect of codeine in the body, therefore codeine must not be used with naltrexone.

Any other medications that increase drowsiness should be used with caution with guaifenesin and codeine.

PREGNANCY: There are no adequate studies with guaifenesin and codeine to determine its safety and effectiveness in pregnant women.

NURSING MOTHERS: Guaifenesin with codeine is excreted in breast milk; therefore, it must be used with caution in nursing mothers.

SIDE EFFECTS: Side effects of guaifenesin with codeine are constipation, nausea, vomiting, sedation, orthostatic hypotension (low blood pressure upon standing), irregular heartbeats, decreased urination, drowsiness, and headache.


Codeine/guaifenesin - Prescribing Information

Medscape Drug Reference. Codeine/guaifenesin

Micromedex Drug Information

Medically Reviewed by a Doctor on 4/16/2014

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