guaifenesin and codeine phosphate (Cheratussin AC, Tussi-Organidin NR, Mytussin AC)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: Guaifenesin and codeine phosphate
BRAND NAME: Cheratussin AC, Tussi-Organidin NR, Mytussin AC
DRUG CLASS AND MECHANISM: Guaifenesin with codeine is an oral, liquid cough medicine. Guaifenesin is an expectorant, which works by thinning and increasing the volume of mucus. Codeine is a narcotic cough suppressant that works by suppressing the cough reflex in the brain, eventually reducing the frequency of cough.
GENERIC AVAILABLE: Yes
PREPARATIONS: Guaifenesin with codeine phosphate is available as an oral liquid. One teaspoon (5 ml) of liquid contains 10 mg of codeine phosphate and 100 mg or 300 mg of guaifenesin.
STORAGE: Guaifenesin and codeine liquid should be stored between 15 C to 30 C (59 F 86 F).
DRUG INTERACTIONS: Naltrexone (Riva) decreases the effect of codeine in the body; therefore codeine must not be used with naltrexone.
Any other medications that increase drowsiness should be used with caution with guaifenesin and codeine.
PREGNANCY: There are no adequate studies with guaifenesin and codeine to determine its safety and effectiveness in pregnant women.
NURSING MOTHERS: Guaifenesin with codeine is excreted in breast milk; therefore, it must be used with caution in nursing mothers.
SIDE EFFECTS: Side effects of guaifenesin with codeine are constipation, nausea, vomiting, sedation, orthostatic hypotension (low blood pressure upon standing), irregular heartbeats, decreased urination, drowsiness, and headache.
Last Editorial Review: 4/23/2014
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