guaifenesin and phenylephrine, Sudafed PE Non-Drying Sinus Caplets, (Entex, discontinued) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: Guaifenesin/phenylephrine may be taken with or without food. It must be used cautiously in patients with heart (coronary artery) disease and angina, and diabetes.

DRUG INTERACTIONS: Guaifenesin/phenylephrine should not be taken with MAO inhibitors drugs due to the increased risk of serious adverse effects

PREGNANCY: Phenylephrine can cause birth defects in some animal species. Additionally, there have been associations between first trimester exposure to these medications and malformations, primarily minor malformations. Although one analysis found a correlation between guaifenesin use in the first trimester of pregnancy and an increased risk of hernia, others found no increased risk of malformations. Thus, guaifenesin/phenylephrine should be used in pregnancy only if the physician feels that the potential benefits outweigh the potential risks.

NURSING MOTHERS: Small amounts of phenylephrine is excreted in breast milk.

SIDE EFFECTS: Side effects of guaifenesin/phenylephrine and include stimulation of the nervous system leading to nervousness, restlessness, excitability, dizziness, headache, fear, anxiety, tremor, and even hallucinations and convulsions (seizures). Nausea, vomiting, and rash also occur.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 5/27/2014


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index