guaifenesin and phenylephrine, Sudafed PE Non-Drying Sinus Caplets, (Entex, discontinued)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREGNANCY: Phenylephrine can cause birth defects in some animal species. Additionally, there have been associations between first trimester exposure to these medications and malformations, primarily minor malformations. Although one analysis found a correlation between guaifenesin use in the first trimester of pregnancy and an increased risk of hernia, others found no increased risk of malformations. Thus, guaifenesin/phenylephrine should be used in pregnancy only if the physician feels that the potential benefits outweigh the potential risks.

NURSING MOTHERS: Small amounts of phenylephrine is excreted in breast milk.

SIDE EFFECTS: Side effects of guaifenesin/phenylephrine and include stimulation of the nervous system leading to nervousness, restlessness, excitability, dizziness, headache, fear, anxiety, tremor, and even hallucinations and convulsions (seizures). Nausea, vomiting, and rash also occur.

Reference: FDA Prescribing Information

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