guaifenesin and phenylephrine, Sudafed PE Non-Drying Sinus Caplets, (Entex, discontinued)

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GENERIC NAME: guaifenesin and phenylephrine

BRAND NAME: Sudafed PE Non-Drying Sinus Caplets, (Entex, discontinued)

DRUG CLASS AND MECHANISM: Guaifenesin/phenylephrine is a medication that contains two different drugs, an expectorant (guaifenesin) and a decongestant (phenylephrine). The expectorant effects of guaifenesin promote drainage of mucus from the lungs by thinning the mucus. It also lubricates the irritated respiratory tract. Phenylephrine relieves stuffy nose by constricting blood vessels in the nasal air passages. This reduces the flow of fluid out of the blood vessels and into the tissues of the air passages.

PRESCRIPTION: No

GENERIC AVAILABLE: yes

PREPARATIONS: Caplet: 5 mg/200 mg

STORAGE: Store at room temperature below 30 C (86 F).

PRESCRIBED FOR: Guaifenesin/phenylephrine is used for the temporary relief of runny nose, sneezing, nasal congestion from the common cold, sinusitis, bronchitis, or sore throat.

DOSING: Guaifenesin/phenylephrine may be taken with or without food. It must be used cautiously in patients with heart (coronary artery) disease and angina, and diabetes.

DRUG INTERACTIONS: Guaifenesin/phenylephrine should not be taken with MAO inhibitors drugs due to the increased risk of serious adverse effects

PREGNANCY: Phenylephrine can cause birth defects in some animal species. Additionally, there have been associations between first trimester exposure to these medications and malformations, primarily minor malformations. Although one analysis found a correlation between guaifenesin use in the first trimester of pregnancy and an increased risk of hernia, others found no increased risk of malformations. Thus, guaifenesin/phenylephrine should be used in pregnancy only if the physician feels that the potential benefits outweigh the potential risks.

NURSING MOTHERS: Small amounts of phenylephrine is excreted in breast milk.

SIDE EFFECTS: Side effects of guaifenesin/phenylephrine and include stimulation of the nervous system leading to nervousness, restlessness, excitability, dizziness, headache, fear, anxiety, tremor, and even hallucinations and convulsions (seizures). Nausea, vomiting, and rash also occur.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 5/27/2014



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