- What is griseofulvin-oral tablet, and how does it work (mechanism of action)?
- What brand names are available for griseofulvin-oral tablet?
- Is griseofulvin-oral tablet available as a generic drug?
- Do I need a prescription for griseofulvin-oral tablet?
- What are the side effects of griseofulvin-oral tablet?
- What is the dosage for griseofulvin-oral tablet?
- Which drugs or supplements interact with griseofulvin-oral tablet?
- Is griseofulvin-oral tablet safe to take if I'm pregnant or breastfeeding?
- What else should I know about griseofulvin-oral tablet?
What is the dosage for griseofulvin-oral tablet?
- The recommended dose is 375 mg daily or 250 mg three times daily of the ultramicrosize formulation depending on the type of infection.
- The dosing recommendation for the microsize formulation is 500 mg once or twice daily, or 1000 mg as a single dose depending on the type of fungal infection.
The duration of treatment varies and is generally continued until the fungal infection is completed eradicated. It is usually taken for
- 2 to 4 weeks for skin infections,
- 4 to 6 weeks for hair and scalp infections,
- 4 to 8 weeks for foot infections,
- 3 to 4 months for fingernail infections, and
- a minimum of at least 6 months for toenail infections.
Which drugs or supplements interact with griseofulvin-oral tablet?
- Griseofulvin increases the activity of CYP3A4 liver enzymes. Griseofulvin should not be combined with other drugs that are metabolized (broken down) by CYP3A4 enzymes because griseofulvin may decrease their blood concentrations, decreasing treatment effectiveness. Examples of drugs metabolized by CYP3A4 enzymes include atazanavir (Reyataz), bedaquiline (Sirturo), daclatasvir (Daklinza), darunavir (Prezista), gefitinib (Iressa), nilotinib (Tasigna), palbociclib (Ibrance), telithromycin (Ketek), and several other drugs.
- Use of griseofulvin with birth control pills may reduce the effectiveness of birth control pills and cause breakthrough bleeding. Patients should use an alternative or additional form of birth control (contraception) while on griseofulvin therapy and for up to 1 month after stopping treatment.
- The effectiveness of warfarin (Coumadin, Jantoven) may be reduced by griseofulvin because griseofulvin may increase the breakdown warfarin by enzymes in the liver.
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