GENERIC NAME: griseofulvin
BRAND NAME: Gris-Peg, Grifulvin V, Griseofulvin Ultramicrosize
DISCONTINUED BRANDS: Fulvicin P/G, Fulvicin U/F, Grisactin, Grisactin Ultra, Ultragris
DRUG CLASS AND MECHANISM: Griseofulvin is an oral antibiotic that is used to treat fungal infections of the skin, body, hair/beard, or nails. Griseofulvin prevents fungal cells from dividing and multiplying. Griseofulvin also is deposited in keratin cells on the surface of the skin making it difficult for fungus to invade the skin and other tissues. Griseofulvin is effective against Microsporum, Epidermophyton and Trichophyton. It is not effective against bacteria. The FDA approved griseofulvin in 1959.
PRESCRIBED FOR: Griseofulvin is used to treat fungal infections including:
- Ringworm of the body (Tinea corporis)
- Athlete's foot (Tinea pedis)
- Ringworm of the groin and thigh (Tinea cruris)
- Barber's itch (Tinea barbae)
- Ringworm of the scalp (Tinea capitis)
- Onychomycosis, ringworm of the nails (Tinea unguium)
SIDE EFFECTS WARNING:
- Severe skin reactions including Steven-Johnson syndrome and toxic epidermal necrolysis have been reported following griseofulvin use. These reactions are serious and can result in hospitalization or death.
- Liver injury has been reported with use of griseofulvin. Elevations in liver enzymes (AST and ALT), bilirubin and jaundice have been reported. These reactions may be serious and may result in hospitalization or death.
Reported side effects include:
- Hypersensitivity type reactions including rashes, itching, and redness
- Angioedema (swelling under the surface of the skin)
- Numbness of the hands and feet
- Oral thrush (fungal infection with Candida Albicans)
- Upset stomach
- Loose stool (diarrhea)
- Difficulty sleeping (insomnia)
- Mental confusion
- Impairment of performance of routine activities
- Presence of abnormal quantities of protein in the urine (proteinuria)
- Reduced white blood cell count (leukopenia)
Quick GuideRingworm: Treatment, Pictures, Causes, and Symptoms
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