granisetron transdermal system (patch), Sancuso (cont.)

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DOSING: A single patch is applied to clean, dry, intact healthy skin on the upper outer arm 24-48 hours before chemotherapy is begun and not removed until at least 24 hours after completion of chemotherapy. The patch may be worn for up to seven days. It should not be applied on skin that is red, irritated, or damaged because of concerns about increasing inflammation and increased absorption of drug. Each patch is packed in a pouch and should be applied immediately after the pouch has been opened. The patch should not be cut into pieces.

DRUG INTERACTIONS: Drug interaction studies have not been conducted with granisetron. Granisetron is broken down in the body by cytochrome P-450 liver enzymes. Drugs that increase (for example, phenobarbital) or decrease (for example, ketoconazole [Nizoral, Extina, Xolegel, Kuric]) the activity of cytochrome P-450 liver enzymes may affect the levels of granisetron in the body.

PREGNANCY: There are no adequate studies of granisetron use in pregnant women. It should only be used during pregnancy if its need outweighs the unknown risks.

NURSING MOTHERS: It is not known whether granisetron is excreted in breast milk. Nursing mothers should consider not breastfeeding.

SIDE EFFECTS: The most common adverse effects of granisetron are constipation and headache. Other adverse effects include anxiety, dizziness, diarrhea, abdominal pain, and chest pain.

Allergic reactions may occur rarely.

Application site reactions (redness, bumps, rashes, blisters) may occur. The patch must be removed if serious skin reactions or generalized skin reactions occur. Light exposure (sunlight, sun lamps, tanning beds) may reduce the effect of granisetron, and granisetron may cause light sensitivity. To avoid light exposure, the application site should be covered with clothing during therapy and for 10 days after the patch is removed. Granisetron may mask the symptoms of certain gastrointestinal conditions, for example, gastroparesis or ileus (paralysis of the muscles of the stomach and small intestine, respectively) by reducing the nausea and vomiting that are their primary symptoms.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 8/1/2014


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