granisetron transdermal system (patch), Sancuso (cont.)

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PREPARATIONS: Transdermal patch delivering 3.1 mg/24 h

STORAGE: Sancuso should be store in the original package at 15 C and 30 C (59 F and 86 F).

PRESCRIBED FOR: Granisetron patches are used for prevention of nausea and vomiting in patients receiving five consecutive days of chemotherapy that is associated with nausea and vomiting.

DOSING: A single patch is applied to clean, dry, intact healthy skin on the upper outer arm 24-48 hours before chemotherapy is begun and not removed until at least 24 hours after completion of chemotherapy. The patch may be worn for up to seven days. It should not be applied on skin that is red, irritated, or damaged because of concerns about increasing inflammation and increased absorption of drug. Each patch is packed in a pouch and should be applied immediately after the pouch has been opened. The patch should not be cut into pieces.

DRUG INTERACTIONS: Drug interaction studies have not been conducted with granisetron. Granisetron is broken down in the body by cytochrome P-450 liver enzymes. Drugs that increase (for example, phenobarbital) or decrease (for example, ketoconazole [Nizoral, Extina, Xolegel, Kuric]) the activity of cytochrome P-450 liver enzymes may affect the levels of granisetron in the body.

PREGNANCY: There are no adequate studies of granisetron use in pregnant women. It should only be used during pregnancy if its need outweighs the unknown risks.

NURSING MOTHERS: It is not known whether granisetron is excreted in breast milk. Nursing mothers should consider not breastfeeding.

SIDE EFFECTS: The most common adverse effects of granisetron are constipation and headache. Other adverse effects include anxiety, dizziness, diarrhea, abdominal pain, and chest pain.

Medically Reviewed by a Doctor on 8/1/2014

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