GENERIC NAME: granisetron transdermal system (patch)
BRAND NAME: Sancuso
DRUG CLASS AND MECHANISM: Sancuso is granisetron delivered via a transdermal patch system for the prevention of nausea and vomiting resulting from chemotherapy for cancer. Other formulations of granisetron (for example, Kytril) are administered by mouth or injection. Certain chemotherapeutic agents used for treating cancer stimulate the release of a neurotransmitter called serotonin from nerves in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. Released serotonin binds to other nerves in an area of the brain called the chemoreceptor trigger zone, causing nausea and vomiting. Granisetron, the active ingredient in Sancuso, prevents serotonin from binding to nerves in the chemoreceptor trigger zone thereby preventing nausea and vomiting. The FDA approved Sancuso in September 2008.
GENERIC AVAILABLE: No
PREPARATIONS: Transdermal patch delivering 3.1 mg/24 h
STORAGE: Sancuso should be store in the original package at 15 C and 30 C (59 F and 86 F).
PRESCRIBED FOR: Granisetron patches are used for prevention of nausea and vomiting in patients receiving five consecutive days of chemotherapy that is associated with nausea and vomiting.
DOSING: A single patch is applied to clean, dry, intact healthy skin on the upper outer arm 24-48 hours before chemotherapy is begun and not removed until at least 24 hours after completion of chemotherapy. The patch may be worn for up to seven days. It should not be applied on skin that is red, irritated, or damaged because of concerns about increasing inflammation and increased absorption of drug. Each patch is packed in a pouch and should be applied immediately after the pouch has been opened. The patch should not be cut into pieces.
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