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February 10, 2012
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granisetron - injection, Kytril

GENERIC NAME: GRANISETRON - INJECTION (gra-NIS-e-tron)

BRAND NAME(S): Kytril

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). It is also used to prevent and treat nausea and vomiting after surgery.Granisetron belongs to a class of medications called 5-HT3 blockers. It works by blocking one of the body's natural substances (serotonin) that can cause vomiting.

HOW TO USE: This drug is given into a vein as directed by your doctor, usually 30 minutes before cancer chemotherapy or before/during/after surgery. The drug may be given directly into a vein over 30 seconds, or it may be mixed in an IV fluid and given into a vein over a longer time (5 minutes).If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.Do not mix granisetron with other drugs in the same injection or inject other drugs into the same vein at the same time. If you have questions about using this medication properly, consult your pharmacist.Dosage is based on your medical condition and response to treatment. The dosage may also be based on weight. Use this medication exactly as directed to get the most benefit from it. Do not use more medication or use it more often than prescribed. Ask your doctor or pharmacist if you have questions.Tell your doctor if your nausea does not improve or if it worsens.

SIDE EFFECTS: Headache, diarrhea, dizziness, fever, or pain/redness/swelling at the injection site may occur. If any of these effects persist or worsen, tell your doctor promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: stomach/abdominal pain.Get medical help right away if any of these rare but serious side effects occur: chest pain, fast/irregular heartbeat, severe dizziness, fainting.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.




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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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granisetron - injection, Kytril

Introduction to nausea and vomiting

Nausea and vomiting are symptoms of an underlying disease and not a specific illness. Nausea is the sensation that the stomach wants to empty itself, while vomiting (emesis) or throwing up, is the act of forcible emptying of the stomach.

Vomiting is a violent act in which the stomach has to overcome the pressures that are normally in place to keep food and secretions within the stomach. The stomach almost turns itself inside out - forcing itself into the lower portion of the esophagus (the tube that connects the mouth to the stomach) during a vomiting episode.

What causes nausea or vomiting?

There are numerous causes of nausea and vomiting. These symptoms may be due to the following:

  • acute gastritis
  • central causes (signals from the brain)
  • association with other illnesses remote from the stomach
  • medications and medical treatments
  • ...

Read the Nausea and Vomiting article »




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