golimumab (Simponi, Simponi Aria)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: golimumab

BRAND NAME: Simponi, Simponi Aria

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

USES: Golimumab is used in combination with methotrexate (Rheumatrex, Trexall) for treating rheumatoid arthritis and alone or combined with methotrexate for treating psoriatic arthritis. It also is used for treating ankylosing spondylitis.

SIDE EFFECTS: The most common side effects of golimumab are

Other side effects include:

  • injection site reactions (redness, swelling),
  • reduced levels of blood cells,
  • reactivation of hepatitis B virus, and
  • new onset or worsening of psoriasis.

Less common side effects include:

  • congestive heart failure,
  • dizziness,
  • hypertension,
  • skin rash, and
  • constipation

Possible serious side effects include:

Individuals with active infections should not be treated with golimumab. Golimumab may worsen or cause new diseases of the nervous system. Golimumab also may cause or worsen congestive heart failure. In studies, some patients who used golimumab or other TNFα blocking drugs developed cancer.

PREPARATIONS: Injection (Prefilled Syringe): 50 mg/0.5 ml

DRUG INTERACTIONS: Combining anakinra (Kineret), abatacept (Orencia), rituximab (Rituxan) with golimumab may result in a reduction of white blood cells in the blood (neutropenia), serious infections and no additional benefit. Golimumab may interfere with the effectiveness of vaccines. Live vaccines, including attenuated vaccines, should not be given to patients receiving golimumab.

Medically Reviewed by a Doctor on 3/3/2016

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