glycopyrrolate (Robinul, Robinul Forte, Cuvposa, Glycate)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

woman with abdominal pain

STORAGE: Store Glycopyrrolate injection at room temperature between 20 C and 25 C (68 F and 77 F).

DOSING:

Adults

  • Preanesthetic medication: Inject 0.004 mg/kg intramuscularly or intravenously 30 to 60 minutes prior to surgery.
  • Intraoperative medication: Inject 0.1 mg as a single dose intravenously every 2 to 3 minutes as needed.
  • Reversal of neuromuscular blockade: Inject 0.2 mg for each 1 mg of neostigmine or 5 mg of pyridostigmine given.
  • Peptic ulcer: Inject 0.1 mg intramuscularly or intravenously at 4-hour intervals, up to 3 to 4 times daily. May increase to 0.2 mg if needed.

Children

  • Preanesthetic medication (children over 2 years of age): Inject 0.004 mg/kg intramuscularly, given 30 to 60 minutes prior to anesthesia, narcotic, or sedative.
  • Preanesthetic medication (Infants of 1 month to 2 years of age): Inject up to 0.009 mg/kg.
  • Intraoperative medication: Inject 0.004 mg/kg as single dose intravenously every 2 to 3 minutes as needed. Do not exceed 0.1 mg in a single dose.
  • Reversal of neuromuscular blockade: Inject 0.2 mg for each 1 mg of neostigmine or 5 mg of pyridostigmine given.

Glycopyrrolate Injection is not recommended for the treatment of peptic ulcer in pediatric patients.

DRUG INTERACTIONS: Glycopyrrolate should not be used with anti-cholinergic drugs such as phenothiazines, Parkinson's drugs, or tricyclic antidepressants because it can significantly increase anticholinergic side effects like mydriasis (pupil dilation), high blood pressure (hypertension), flushing, fever, and increased heart rate.

Medically Reviewed by a Doctor on 10/7/2015

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Digestive Disorders: Common Misconceptions
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