GENERIC NAME: glycopyrrolate
BRAND NAME: Robinul, Robinul Forte, Cuvposa, Glycate
DRUG CLASS AND MECHANISM: Glycopyrrolate is a synthetic anti-cholinergic medication. Glycopyrrolate works by blocking acetylcholine activity on smooth muscles and other tissues. Acetylcholine is neurotransmitter, a chemical that nerves use for communicating. Blocking of acetylcholine leads to decrease in volume and acidity of stomach secretions and decrease in pharyngeal, tracheal, and bronchial secretions. It also reverses symptoms of excessive bronchial secretions, bronchospasm, low heart rate, and intestinal hypermotility caused by medications that increase the action of acetylcholine. The FDA approved glycopyrrolate in August 1961.
PRESCRIBED FOR: Glycopyrrolate injection is used as preoperative medication to prevent secretions during surgery, to reverse irregular heart rate, and to reverse neuromuscular (neurons and muscles) blockade. It is also used as adjunct therapy in peptic ulcer disease to produce rapid anti-cholinergic effects when oral therapy is not tolerated.
SIDE EFFECTS: Common side effects of glycopyrrolate are:
- dry mouth,
- urinary retention,
- blurred vision,
- dilated pupils,
- increased heart rate,
- dry skin,
- urinary retention, and
- mental confusion.
This drug should not be used in patients with glaucoma.
GENERIC AVAILABLE: Yes
PREPARATIONS: Glycopyrrolate injection is available in 0.2 mg/ml strength in 1 ml and 2 ml single-use vials. It is also available in 5 ml and 20 ml multi-use vials. All vials contain benzyl alcohol 0.9% as preservative.
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