glycopyrrolate (Robinul, Robinul Forte, Cuvposa, Glycate)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

GENERIC NAME: glycopyrrolate

BRAND NAME: Robinul, Robinul Forte, Cuvposa, Glycate

DRUG CLASS AND MECHANISM: Glycopyrrolate is a synthetic anti-cholinergic medication. Glycopyrrolate works by blocking acetylcholine activity on smooth muscles and other tissues. Acetylcholine is neurotransmitter, a chemical that nerves use for communicating. Blocking of acetylcholine leads to decrease in volume and acidity of stomach secretions and decrease in pharyngeal, tracheal, and bronchial secretions. It also reverses symptoms of excessive bronchial secretions, bronchospasm, low heart rate, and intestinal hypermotility caused by medications that increase the action of acetylcholine. The FDA approved glycopyrrolate in August 1961.

PRESCRIBED FOR: Glycopyrrolate injection is used as preoperative medication to prevent secretions during surgery, to reverse irregular heart rate, and to reverse neuromuscular (neurons and muscles) blockade. It is also used as adjunct therapy in peptic ulcer disease to produce rapid anti-cholinergic effects when oral therapy is not tolerated.

SIDE EFFECTS: Common side effects of glycopyrrolate are:

This drug should not be used in patients with glaucoma.



PREPARATIONS: Glycopyrrolate injection is available in 0.2 mg/ml strength in 1 ml and 2 ml single-use vials. It is also available in 5 ml and 20 ml multi-use vials. All vials contain benzyl alcohol 0.9% as preservative.

Medically Reviewed by a Doctor on 10/7/2015

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