Glycine

Are there any interactions with medications?

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Clozapine (Clozaril)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Clozapine (Clozaril) is used to help treat schizophrenia. Taking glycine along with clozapine (Clozaril) might decrease the effectiveness of clozapine (Clozaril). It is not clear why this interaction occurs yet. Do not take glycine if you are taking clozapine (Clozaril).

Dosing considerations for Glycine.

The following doses have been studied in scientific research:

BY MOUTH:

• For treating schizophrenia: Glycine has been used in doses ranging from 0.4 to 0.8 g/kg daily in divided doses. It is usually started at 4 g daily and increased by 4 g per day until the effective dose is reached.

UNDER THE TONGUE:

• For protecting brain cells (neuroprotection) after onset on a stroke caused by a clot (ischemic stroke): 1 to 2 g per day started within 6 hours after stroke onset.

APPLIED TO THE SKIN:

• For treating leg ulcers: A cream containing 10 mg of glycine, 2 mg of L-cysteine, and 1 mg of DL-threonine per gram of cream has been used. The cream was applied at each wound cleaning and dressing change once daily, every other day, or twice daily.