Glucovance (glyburide/metformin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is glyburide/metformin tablets-oral, and how does it work (mechanism of action)?

  • Glucovance (glyburide/metformin) is a combination antidiabetic medication containing glyburide and metformin. Glucovance is used to improve blood glucose (sugar) control in adults with type 2 diabetes mellitus.
  • Glyburide is a second generation oral sulfonylurea. It helps to lower blood glucose by stimulating the release of insulin, the hormone responsible for regulating blood glucose.
  • Metformin is an oral biguanide antidiabetic agent. It decreases the production of glucose in the liver, decreases the absorption of glucose by the intestines, and increases the uptake and use of blood glucose by cells throughout the body.
  • In clinical studies, glyburide/metformin therapy was observed to be superior in improving fasting plasma glucose, post-meal blood glucose, and HbA1c levels versus treatment with glyburide or metformin alone.
  • Glucovance was approved by the FDA in July, 2000.

What brand names are available for glyburide/metformin tablets-oral?


Is glyburide/metformin tablets-oral available as a generic drug?


Do I need a prescription for glyburide/metformin tablets-oral?


What are the uses for glyburide/metformin tablets-oral?

Glucovance is used as an adjunct to diet and exercise to improve blood glucose control in adults with type 2 diabetes.

What are the side effects of glyburide/metformin tablets-oral?

The most common side effects include

Other commonly reported side effects with Glucovance therapy include

Other side effects include

Metformin can cause a rare but serious condition known as lactic acidosis, a build-up of acid in the blood. Lactic acidosis can cause death and requires immediate treatment. Symptoms of lactic acidosis include

Patients suspected of having signs or symptoms of lactic acidosis must seek emergency medical help.

Medically Reviewed by a Doctor on 8/31/2016

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