GENERIC NAME: glyburide
BRAND NAMES: Micronase, Diabeta, Glynase Prestab
DRUG CLASS AND MECHANISM: Glyburide is an oral, glucose-lowering drug in a class of diabetic drugs called sulfonylureas that is used for treating diabetes. Other sulfonylureas include glipizide (Glucotrol), glimepiride (Amaryl), tolbutamide (Orinase), tolazamide, and chlorpropamide (Diabinese). Insulin is a hormone that is made in the pancreas. When released into the blood, insulin reduces the formation of glucose by the liver and causes cells in the body to remove the glucose (“sugar”) from the blood. Patients with type 2 diabetes have high glucose levels in their blood because the cells in their bodies are resistant to the effect of insulin, and the pancreas cannot produce enough insulin to overcome the insulin resistance of the body's cells. As a result, their liver produces and releases too much glucose. In addition, Glyburide reduces glucose in the blood by stimulating the pancreas to produce more insulin. Glyburide is not a cure for diabetes. The FDA approved glyburide in May 1984.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 1.25, 2.5, and 5 mg. Tablets (micronized): 1.5, 3, 5, and 6 mg.
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