glyburide, Micronase, Diabeta, Glynase, Prestab

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GENERIC NAME: glyburide

BRAND NAMES: Micronase, Diabeta, Glynase Prestab

DRUG CLASS AND MECHANISM: Glyburide is an oral glucose lowering-drug in a class of diabetic drugs called sulfonylureas. Other sulfonylureas include glipizide (Glucotrol), glimepiride (Amaryl), tolbutamide (Orinase), tolazamide, and chlorpropamide (Diabinese). Insulin is a hormone that is made in the pancreas. When released into the blood, insulin reduces the formation of glucose by the liver and causes cells in the body to remove sugar (glucose) from the blood. Patients with type 2 diabetes have high glucose levels in their blood because the cells in their bodies are resistant to the effect of insulin. Their liver produces too much glucose. In addition, the pancreas cannot produce enough insulin to overcome the insulin resistance of the body's cells. Glyburide reduces blood glucose by stimulating the pancreas to produce more insulin. Glyburide is not a cure for diabetes. The FDA approved glyburide in May 1984.



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