Glucosamine Hydrochloride

Are there any interactions with medications?



Warfarin (Coumadin)
Interaction Rating: Major Do not take this combination.

Warfarin (Coumadin) is used to slow blood clotting. There are several reports showing that taking glucosamine hydrochloride with or without chondroitin increases the effect of warfarin (Coumadin) on blood clotting. This can cause bruising and bleeding that can be serious. Don't take glucosamine hydrochloride if you are taking warfarin (Coumadin).



Medications for cancer (Antimitotic chemotherapy)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications for cancer work by decreasing how fast cancer cells can copy themselves. Some scientists think that glucosamine might increase how fast tumor cells can copy themselves. Taking glucosamine hydrochloride along with some medications for cancer might decrease the effectiveness of these medications.



Acetaminophen (Tylenol, others)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

There is some concern that taking glucosamine hydrochloride and acetaminophen (Tylenol, others) together might affect how well each works. But more information is needed to know if this interaction is a big concern.



Medications for diabetes (Antidiabetes drugs)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

There has been concern that glucosamine hydrochloride might increase blood sugar in people with diabetes. There was also the concern that glucosamine hydrochloride might decrease how well medications used for diabetes work. However, research now indicates that glucosamine hydrochloride probably does not increase blood sugar in people with diabetes. Therefore, glucosamine hydrochloride probably does not interfere with diabetes medications. To be cautious, if you take glucosamine hydrochloride and have diabetes, monitor your blood sugar closely.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing considerations for Glucosamine Hydrochloride.

The appropriate dose of glucosamine hydrochloride depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for glucosamine hydrochloride. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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