Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.
Cimetidine (Tagamet), by decreasing the elimination of metformin from the
body, can increase the amount of metformin in the blood by 40%. This may
increase the frequency of side effects from metformin.
Alcohol consumption increases the effect of metformin on lactate production,
increasing the risk of lactic acidosis.
Due to the risk of lactic acidosis, metformin containing products must be
temporarily discontinued prior to the administration of radiopaque contrast
Metformin should be held for at least 48 hours after contrast dye
administration and should not be restarted until patient's kidney function
returns back to normal.
Beta blockers may increase the blood glucose lowering actions of
sulfonylureas. Cardio-selective beta blockers such as
metoprolol (Lopressor or Toprol XL), and penbutolol
(Levatol) may be safer than their nonselective counterparts.
Colesevelam (Welchol) may reduce blood levels of glipizide. Patients are
advised to take glipizide 1 hour before or 4 hours after colesevelam
administration to minimize the risk of their interaction.