GENERIC NAME: glipizide/metformin hydrochloride
BRAND NAME: None
DISCONTINUED BRAND: Metaglip
GENERIC AVAILABLE: Yes
SIDE EFFECTS: The most common side effects associated with glipizide/metformin treatment are:
- High blood pressure
- Muscle or joint pain
- Upper respiratory tract infection
- Urinary tract infection (UTI)
Side effects related to the stomach were most commonly reported by patients who newly started treatment with glipizide/metformin and included:
Other less common but potentially serious side effects include:
- Blood disorders
- Liver disease
- Kidney disease
- Photosensitivity (sun sensitivity)
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Ovulation induction
- Low sodium levels (hyponatremia)
- Disulfiram-like reactions (for example, heart palpitations, nausea, vomiting, dizziness, and headache)
- Hypersensitivity type reactions
Metformin can cause a rare but serious condition known as lactic acidosis, a build-up of acid in the blood. Lactic acidosis can cause death and requires immediate treatment.
Symptoms of lactic acidosis include:
- Unusual muscle pain
- Pain in the stomach
- Difficulty breathing
- Slow or irregular heartbeat
Patients suspected of presenting with signs or symptoms of lactic acidosis must seek emergency medical help.
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