glipizide/metformin (Metaglip)

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GENERIC NAME: glipizide/metformin hydrochloride

BRAND NAME: Metaglip

DRUG CLASS AND MECHANISM: Glipizide/metformin (glipizide/metformin) is a combination antidiabetic medication that contains two commonly used glucose (sugar) lowering agents, glipizide (Glucotrol) and metformin (Glucophage). These agents work in different, yet complementary ways to improve blood glucose control in patients with type 2 diabetes.

  • Glipizide is a second generation oral sulfonylurea that lowers blood glucose by stimulating the production of insulin from the pancreas. It is the major hormone responsible for regulating blood sugar.
  • Metformin is an oral biguanide antidiabetic medication that decreases the production of glucose in the liver, decreases the absorption of glucose by the intestines, and increases response to insulin.

In clinical studies, glipizide/metformin therapy was superior in improving fasting plasma glucose, postprandial plasma glucose (blood glucose levels after a meal), and HbA1c versus treatment with either agent alone.

Glipizide/metformin was approved by the FDA in October 2002.

Medically Reviewed by a Doctor on 2/5/2015

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