glipizide/metformin (Metaglip)

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Medical and Pharmacy Editor:

GENERIC NAME: glipizide/metformin hydrochloride

BRAND NAME: Metaglip

DRUG CLASS AND MECHANISM: Glipizide/metformin (glipizide/metformin) is a combination antidiabetic medication that contains two commonly used glucose (sugar) lowering agents, glipizide (Glucotrol) and metformin (Glucophage). These agents work in different, yet complementary ways to improve blood glucose control in patients with type 2 diabetes.

  • Glipizide is a second generation oral sulfonylurea that lowers blood glucose by stimulating the production of insulin from the pancreas. It is the major hormone responsible for regulating blood sugar.
  • Metformin is an oral biguanide antidiabetic medication that decreases the production of glucose in the liver, decreases the absorption of glucose by the intestines, and increases response to insulin.
Medically Reviewed by a Doctor on 2/5/2015

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