- What is glipizide/metformin hydrochloride?
- What brand names are available for glipizide/metformin hydrochloride?
- Is glipizide/metformin hydrochloride available as a generic drug?
- Do I need a prescription for glipizide/metformin hydrochloride?
- What are the uses for glipizide/metformin hydrochloride?
- What are the side effects of glipizide/metformin hydrochloride?
- What is the dosage for glipizide/metformin hydrochloride?
- Which drugs or supplements interact with glipizide/metformin hydrochloride?
- Is glipizide/metformin hydrochloride safe to take during pregnancy or while breastfeeding?
- What else should I know about glipizide/metformin hydrochloride?
What is glipizide/metformin hydrochloride?
Glipizide/metformin is a
combination antidiabetic medication that contains two commonly used glucose
lowering agents, glipizide (Glucotrol) and metformin (Glucophage). These agents
work in different, yet complementary ways to improve
blood glucose control in
type 2 diabetes.
- Glipizide is a second generation oral sulfonylurea that lowers blood glucose by stimulating the production of insulin from the pancreas. It is the major hormone responsible for regulating blood sugar.
- Metformin is an oral biguanide antidiabetic medication that decreases the production of glucose in the liver, decreases the absorption of glucose by the intestines, and increases response to insulin.
- In clinical studies, glipizide/metformin therapy was superior in improving fasting plasma glucose, postprandial plasma glucose (blood glucose levels after a meal), and HbA1c versus treatment with either agent alone.
- Combination glipizide and metformin was approved by the FDA in October 2002.
What brand names are available for glipizide/metformin hydrochloride?
- There are no brand names available for glipizide/metformin hydrochloride in the US.
- Metaglip is a discontinued brand name for glipizide/metformin hydrochloride.
Is glipizide/metformin hydrochloride available as a generic drug?
Do I need a prescription for glipizide/metformin hydrochloride?
What are the uses for glipizide/metformin hydrochloride?
- Glipizide/metformin is used as an adjunct to diet and exercise to improve blood glucose control in adults with type 2 diabetes.
What are the side effects of glipizide/metformin hydrochloride?
The most common side effects associated with glipizide/metformin treatment are:
- High blood pressure
- Muscle or joint pain
- Upper respiratory tract infection
- Urinary tract infection (UTI)
Side effects related to the stomach were most commonly reported by patients who newly started treatment with glipizide/metformin and included:
Other less common but potentially serious side effects include:
- Blood disorders
- Liver disease
- Kidney disease
- Photosensitivity (sun sensitivity)
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Ovulation induction
- Low sodium levels (hyponatremia)
- Disulfiram-like reactions (for example, heart palpitations, nausea, vomiting, dizziness, and headache)
- Reduced number of platelets
- Reduced number of white blood cells
- Hypersensitivity type reactions
Metformin can cause a rare but serious condition known as lactic acidosis, a build-up of acid in the blood. Lactic acidosis can cause death and requires immediate treatment.
Symptoms of lactic acidosis include:
- Unusual muscle pain
- Pain in the stomach
- Difficulty breathing
- Slow or irregular heartbeat
Patients suspected of presenting with signs or symptoms of lactic acidosis must seek emergency medical help.
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