- Alcohol may prolong the action of glipizide by delaying the absorption and elimination of glipizide. Patients taking glipizide should keep alcohol consumption to a minimum.
- Cholestyramine (Questran, Questran Light) may reduce both the absorption and effects of glipizide. Glipizide should therefore be administered 1-2 hours before cholestyramine is given.
- Fluconazole (Diflucan) also can increase the absorption and effects of glipizide.
- Many drugs can potentially increase or decrease glucose levels thus increasing or decreasing the effects of glipizide. Drug interactions
that cause low blood glucose (hypoglycemia) can occur with:
- nonsteroidal anti-inflammatory drugs (for example [ibuprofen]),
- sulfa drugs,
- warfarin (Coumadin),
- miconazole (Oravig),
- fluconazole (Diflucan),
- voriconazole (Vfend),
- beta-blockers (for example, propranolol [Inderal, Inderal LA, Innopran XL]),
- androgens (for example fluoxymesterone [Androxy]),
- cimetidine (Tagamet HB),
- ranitidine (Zantac),
- clarithromycin (Biaxin),
- MAO Inhibitors (for example, isocarboxazid [Marplan] and phenelzine [Nardil]),
- mifepristone (Mifeprex),
- quinolone antibiotics, and
- selective serotonin reuptake inhibitors (for example paroxetine [Paxil], fluoxetine [Prozac], and sertraline [Zoloft].
- Drug interactions involving glipizide which can result in high blood glucose (hyperglycemia) can occur with:
- Rifampin may reduce the blood levels of glipizide and this may result in higher levels of sugar in the blood.
Quick GuideDiabetes: Best and Worst Meals for Diabetes-Savvy Dining
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