glipizide, Glipizide XL, Glucotrol, Glucotrol XL (cont.)

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Skin rashes can occur and cause itching, hives, or a diffuse measles-like rash.

Rare but serious side effects include:

Glipizide also may cause hypoglycemia. The risk of hypoglycemia increases when glipizide is combined with other glucose reducing agents.



PREPARATIONS: : Immediate-release tablets; 5 and 10 mg. Extended-release tablets; 2.5, 5, and 10 mg.

STORAGE: Glipizide should be stored between 15 C and 30 C (59 F and 86 F).


  • The usual starting dose when using immediate release tablets is 5 mg daily administered 30 minutes before a meal.
  • The maximum dose is 40 mg daily.
  • Doses higher than 15 mg per day should be divided and given in divided doses daily.
  • The starting dose when using extended-release tablets is 5 mg daily up to a maximum dose of 20 mg daily.
  • Patients using immediate release tablets may be converted to the nearest equivalent extended-release dose.


  • Alcohol may prolong the action of glipizide by delaying the absorption and elimination of glipizide. Patients taking glipizide should keep alcohol consumption to a minimum.
  • Cholestyramine (Questran, Questran Light) may reduce both the absorption and effects of glipizide. Glipizide should therefore be administered 1-2 hours before cholestyramine is given.
  • Fluconazole (Diflucan) also can increase the absorption and effects of glipizide.
  • Many drugs can potentially increase or decrease glucose levels thus increasing or decreasing the effects of glipizide. Drug interactions that cause low blood glucose (hypoglycemia) can occur with:
  • Drug interactions involving glipizide which can result in high blood glucose (hyperglycemia) can occur with:
  • Rifampin may reduce the blood levels of glipizide and this may result in higher levels of sugar in the blood.
Medically Reviewed by a Doctor on 12/11/2014

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